45 and older, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Medial Knee Contact Forces During WalkingPrimary· Change from before treatment (approximately 1 week prior to the injection visit) to 30 minutes after treatment (the injection).
Contact forces estimated with musculoskeletal modeling
Group
Value
95% CI
Knee Osteoarthritis
-0.04
± 0.02
Change in Lateral Knee Contact Forces During WalkingPrimary· Change from before treatment (approximately 1 week prior to the injection visit) to 30 minutes after treatment (the injection).
Contact forces estimated with musculoskeletal modeling
Group
Value
95% CI
Knee Osteoarthritis
0.02
± 0.03
Change in Patellofemoral Knee Contact Forces During WalkingPrimary· Change from before treatment (approximately 1 week prior to the injection visit) to 30 minutes after treatment (the injection).
Contact forces estimated with musculoskeletal modeling
Group
Value
95% CI
Knee Osteoarthritis
-0.01
± 0.01
Sponsor's own description
The goal of this study is to determine if pain in one knee influences loading of the other knee during different types of walking. The main questions it aims to answer are:
* How does unilateral knee pain affect contralateral knee joint loading during different types of walking?
* Does movement and loading change at the hips, knees, and ankles during prolonged walking in persons with painful knee osteoarthritis?
Participants will:
* Fill out questionnaires/surveys
* Complete clinical examinations
* Walking on a treadmill under different types of walking conditions
* Receive two knee injections For comparison purposes, researchers will also enroll healthy participants.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 29 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05670236.