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NCT05663333: DOCTA
Histopathological Analysis of Temporal Artery Biopsy Following Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Patients With Suspected Giant Cell Arteritis (DOCTA)
trial testing Dynamic full-field optical coherence tomography analysis of temporal artery biopsy in Giant Cell Arteritis in 14 participants. Completed in 31 July 2024.
30 June 2024
Quick facts
| Lead sponsor | Centre Hospitalier William Morey - Chalon sur Saône |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 14 |
| Start date | 26 January 2023 |
| Primary completion | 30 June 2024 |
| Estimated completion | 31 July 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- Dynamic full-field optical coherence tomography analysis of temporal artery biopsy
Conditions studied
- Giant Cell Arteritis — all drugs for Giant Cell Arteritis →
- Tomography, Optical Coherence — all drugs for Tomography, Optical Coherence →
Sponsor
Centre Hospitalier William Morey - Chalon sur Saône
Who can join
50 and older, any sex, with Giant Cell Arteritis or Tomography, Optical Coherence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Giant cell arteritis (GCA) is a type of large vessel granulomatous vasculitis responsible for the inflammation of the aorta and the branches of the external carotid, notably temporal arteries. The diagnosis of GCA relies upon the identification of vasculitis following histopathological analysis of temporal artery biopsy (TAB) showing mononuclear cells infiltration, fragmentation of the internal elastic lamina as well as significant intimal hyperplasia. Apart from its lack of sensitivity, one of the weaknesses of TAB is the delay in obtaining the result due to the time required to prepare the sample for histological analysis. Pursuing the idea to improve TAB performances, our group recently demonstrated the use of full-field optical coherence tomography (FF-OCT) to visualize structural changes associated with the inflammatory processes of GCA. The present work suggests a further use of dynamic FF-OCT on TAB for a direct visualization of the mononuclear cells infiltration to ensure rapid on-site diagnosis of GCA.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05663333
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Giant Cell Arteritis
Currently open trials in the same condition.
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- NCT05935709 — DANIsh VASculitis Database (DANIVAS) · recruiting
- NCT06460142 — Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic · recruiting
- NCT06011512 — Risk of Diabetes Mellitus in Patients With Giant Cell Arthritis and Polymyalgia Rheumatica. · recruiting
Other Centre Hospitalier William Morey - Chalon sur Saône trials
Trials by the same sponsor.
- NCT06611800 — Personalized Advance Prescriptions in Palliative Care at HOME: Interests and Difficulties of Its Implementation · completed
- NCT06216080 — Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Ca · completed
- NCT05728216 — Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conve · recruiting
- NCT05608902 — Structural Description of Skin Biopsies With Dynamic Full-field Optical Coherence Tomography on Suspected Basal Cell Car · completed
- NCT05635136 — Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conve · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05663333 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier William Morey - Chalon sur Saône
- Last refreshed: 22 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05663333.
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