NCT05662085 (PROPXE) is a clinical trial of No intervention in Pseudoxanthoma Elasticum, sponsored by University Hospital, Basel, Switzerland.

Who is sponsoring NCT05662085?

NCT05662085 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT05662085?

Interventions in NCT05662085: No intervention.

What condition does NCT05662085 study?

NCT05662085 studies Pseudoxanthoma Elasticum.

Is NCT05662085 still recruiting?

NCT05662085 is currently active, enrolled. Last updated 22 April 2025.

Last reviewed 2025-04-22 · How we verify

NCT05662085: PROPXE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Progression Rate of Pseudoxanthoma Elasticum-associated Choroidal and Retinal Degeneration

Active, enrolled Last updated 22 April 2025

What this trial tests

trial testing No intervention in Pseudoxanthoma Elasticum in 25 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 October 2022

Primary endpoint
31 October 2025

31 October 2025

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	25
Start date	1 October 2022
Primary completion	31 October 2025
Estimated completion	31 October 2025
Sites	1 location across Switzerland

Drugs / interventions tested

No intervention

Conditions studied

Pseudoxanthoma Elasticum — all drugs for Pseudoxanthoma Elasticum →

Sponsor

University Hospital, Basel, Switzerland

Who can join

18 and older, any sex, with Pseudoxanthoma Elasticum. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to systematically assess the retest reliability and ability to detect a change of new visual function tests and ophthalmological imaging methods for observing the natural course of pseudoxanthoma elasticum (PXE).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Topography of Slowed Dark Adaptation in Pseudoxanthoma Elasticum: PROPXE Study Report 1.
Pfau K, Ansari G, Michels S, Dysli C, et al · · 2025 · cited 5× · PMID 39913163 · DOI 10.1167/iovs.66.2.17
Measurement Reliability and Functional Validity of Bruch's Membrane Calcification in Pseudoxanthoma Elasticum: PROPXE Study Report 2.
Giger JAW, Ansari G, Terry SF, Charbel Issa P, et al · · 2025 · PMID 41230901 · DOI 10.1167/iovs.66.14.29

Verify or expand the search:

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Other recruiting trials for Pseudoxanthoma Elasticum

Currently open trials in the same condition.

NCT05734196 — The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency · Phase 1 · recruiting
NCT05832580 — The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum · Phase 3 · recruiting
NCT04868578 — PPI Supplementation to Fight ECtopIc Calcification in PXE · NA · recruiting

Other University Hospital, Basel, Switzerland trials

Trials by the same sponsor.

NCT07444788 — Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants · Phase 1 · recruiting
NCT07494214 — Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants · Phase 1 · recruiting
NCT07419048 — Artificial Intelligence or Human Hand? Evaluating Inferior Vena Cava Imaging for Hydration Status · recruiting
NCT06978777 — Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity · NA · recruiting
NCT07273630 — Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05662085 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 22 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05662085.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing