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NCT05657457
Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)
Terminated
Phase 3
Last updated 2 July 2025
What this trial tests
Phase 3 trial testing Tenecteplase in Stroke, Ischemic in 145 participants. Terminated before completion.
Timeline
21 March 2023
Primary endpoint
18 May 2025
18 May 2025
18 May 2025
Quick facts
| Lead sponsor | General Hospital of Shenyang Military Region |
|---|---|
| Phase | Phase 3 |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 145 |
| Start date | 21 March 2023 |
| Primary completion | 18 May 2025 |
| Estimated completion | 18 May 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Tenecteplase (TENECTEPLASE) — full drug profile →
Conditions studied
- Stroke, Ischemic — all drugs for Stroke, Ischemic →
Sponsor
General Hospital of Shenyang Military Region
Who can join
18 and older, any sex, with Stroke, Ischemic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The potential benefit of intraarterial tenecteplase in acute basilar artery occlusion (BAO) patients with successful reperfusion following endovascular treatment (EVT) has not been studied. The current study aimed to explore the efficacy and safety of intraarterial tenecteplase in acute BAO patients with successful reperfusion after EVT.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke.
Wang L, Hao M, Wu N, Wu S, et al · · 2024 · cited 48× · PMID 38686848 · DOI 10.1161/jaha.123.031692 -
Hyperacute ischemic stroke care-Current treatment and future directions.
Campbell BC. · · 2024 · cited 18× · PMID 39096172 · DOI 10.1177/17474930241267353 -
Improving neurological outcome for acute basilar artery occlusion with sufficient recanalization after thrombectomy by intraarterial tenecteplase (INSIST-IT): Rationale and design.
Liu L, Li W, Qiu J, Nguyen TN, et al · · 2023 · cited 15× · PMID 37231688 · DOI 10.1177/23969873231164790 -
Intra-Arterial Thrombolysis Following Endovascular Recanalization for Large Vessel Occlusion Stroke: A Systematic Review and Meta-Analysis.
Jiang X, Zhao Z, Zhang Y, Luo W, et al · · 2025 · cited 8× · PMID 40577652 · DOI 10.1212/wnl.0000000000213842 -
Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Doheim MF, Mohammaden MH, Jumah A, Yang Q, et al · · 2025 · cited 6× · PMID 40799167 · DOI 10.1002/ana.70021 -
Tenecteplase versus alteplase in patients with acute ischemic stroke: an updated systematic review and meta-analysis.
Hagag AM, Kormod ME, Ads ME, El-Refaay MA, et al · · 2025 · cited 5× · PMID 40775658 · DOI 10.1186/s40001-025-02983-9 -
Neurointerventional Advances in 2025.
Mehta A, Sheth SA, Jadhav AP. · · 2026 · PMID 42088336 · DOI 10.1161/svin.125.002280 -
Letter to the Editor, Regarding "Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta-Analysis to Determine the Optimal Dose" Recently Published by Waseem and Colleagues.
Frol S, Zupan M, Papanagiotou P. · · 2025 · PMID 41273017 · DOI 10.1002/brb3.71055
Verify or expand the search:
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Related trials
Other trials of Tenecteplase
Trials testing the same drug.
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- NCT07361302 — A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Pe · Phase 3 · recruiting
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Currently open trials in the same condition.
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Other General Hospital of Shenyang Military Region trials
Trials by the same sponsor.
- NCT07375953 — Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK) · Phase 2 · recruiting
- NCT07375966 — Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours · Phase 2 · recruiting
- NCT07462546 — Transcranial Doppler for Internal Carotid Artery Stenting (TCD-ICAS) · NA · recruiting
- NCT07294885 — Deep Cervical LymphatIc-Venous Anastomosis for Alzheimer's Disease · NA · recruiting
- NCT07412249 — Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT05657457 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by General Hospital of Shenyang Military Region
- Last refreshed: 2 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05657457.
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