NCT05640362 is a NA clinical trial of Natural enzymes mouthwash in Xerostomia, sponsored by National University of Malaysia.

Who is sponsoring NCT05640362?

NCT05640362 is sponsored by National University of Malaysia.

What drugs are being tested in NCT05640362?

Interventions in NCT05640362: Natural enzymes mouthwash, Benzydamine mouthwash.

What condition does NCT05640362 study?

NCT05640362 studies Xerostomia, Dry Mouth.

Is NCT05640362 still recruiting?

NCT05640362 is currently completed. Last updated 7 December 2022.

Last reviewed 2022-12-07 · How we verify

NCT05640362

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial

Completed NA Last updated 7 December 2022

What this trial tests

NA trial testing Natural enzymes mouthwash in Xerostomia in 48 participants. Completed in 24 March 2017.

Timeline

10 November 2016

Primary endpoint
9 March 2017

24 March 2017

Quick facts

Lead sponsor	National University of Malaysia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	supportive care
Enrollment	48
Start date	10 November 2016
Primary completion	9 March 2017
Estimated completion	24 March 2017
Sites	1 location across Malaysia

Drugs / interventions tested

Natural enzymes mouthwash
Benzydamine mouthwash

Conditions studied

Xerostomia — all drugs for Xerostomia →
Dry Mouth — all drugs for Dry Mouth →

Sponsor

National University of Malaysia

Who can join

18 and older, any sex, with Xerostomia or Dry Mouth. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical is to assess the efficacy of natural enzymes mouthwash in the treatment of xerostomia (dry mouth). The main questions it aims to answer are: (1) the efficacy of natural enzymes mouthwash in the symptomatic treatment of xerostomia; and (2) the response of xerostomia patients towards natural enzymes mouthwash. Participants were given a mouthwash to be used. Intervention group received natural enzymes moisturising mouthwash, while control group received benzydamine mouthwash. Mouthwashes were repacked, labelled with specific code and were given to participants by third-party. Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks. Data were compared within each arm before and after using the mouthwashes; and between both arms after using the mouthwashes.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Efficacy of natural enzymes mouthwash: a randomised controlled trial.
Chiam TL, Choo J, Ashar A, Hussaini HM, et al · · 2024 · cited 2× · PMID 38639763 · DOI 10.1007/s00784-024-05658-7
Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial
Chiam TL, Choo JCK, Ashar A, Rajandram RK, et al · · 2023 · DOI 10.21203/rs.3.rs-2649277/v1

Verify or expand the search:

Other recruiting trials for Xerostomia

Currently open trials in the same condition.

NCT07394842 — Longitudinal Oral Health Changes After Head and Neck Radiotherapy · active not recruiting
NCT06465628 — Acupressure on Xerostomia in Head and Neck Cancer Patients · NA · recruiting
NCT06365047 — Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine · Phase 3 · active not recruiting
NCT06194123 — Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis · NA · active not recruiting
NCT06287294 — An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer · recruiting

Other National University of Malaysia trials

Trials by the same sponsor.

NCT07251842 — Metabolic Availability of Methionine in Tempeh Chips Among Reproductive-age Women Using Indicator Amino Acid Oxidation ( · NA · not yet recruiting
NCT07362394 — Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Remo · NA · not yet recruiting
NCT07503223 — Sleep Optimization With Acoustic Therapy · NA · recruiting
NCT07432373 — Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection · not yet recruiting
NCT07157397 — Effect of a Plant-Focused Diet on Nutritional Status in Malnourished Peritoneal Dialysis Patients · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05640362 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National University of Malaysia
Last refreshed: 7 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05640362.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing