Who is sponsoring NCT05640284?

NCT05640284 is sponsored by Necmettin Erbakan University.

What drugs are being tested in NCT05640284?

Interventions in NCT05640284: Nuclear Factor-Kappa B Ligand (RANKL) analysis, Osteoprotegerin (OPG) analysis, Tumor Necrosis Factor Alpha (TNF-α) analysis, MicroRNA-223 analysis, Microrna-27a analysis.

What condition does NCT05640284 study?

NCT05640284 studies Alveolar Bone Loss, Dental Implant, Periimplantitis.

Is NCT05640284 still recruiting?

NCT05640284 is currently completed. Last updated 25 January 2023.

Last reviewed 2023-01-25 · How we verify

NCT05640284

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of the Effect of Periimplant Soft Tissue Phenotype on Marginal Bone Loss

Completed Last updated 25 January 2023

What this trial tests

trial testing Nuclear Factor-Kappa B Ligand (RANKL) analysis in Alveolar Bone Loss in 87 participants. Completed in 15 January 2023.

Timeline

2 December 2022

Primary endpoint
15 January 2023

15 January 2023

Quick facts

Lead sponsor	Necmettin Erbakan University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	87
Start date	2 December 2022
Primary completion	15 January 2023
Estimated completion	15 January 2023
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Nuclear Factor-Kappa B Ligand (RANKL) analysis
Osteoprotegerin (OPG) analysis
Tumor Necrosis Factor Alpha (TNF-α) analysis
MicroRNA-223 analysis
Microrna-27a analysis

Conditions studied

Alveolar Bone Loss — all drugs for Alveolar Bone Loss →
Dental Implant — all drugs for Dental Implant →
Periimplantitis — all drugs for Periimplantitis →

Sponsor

Necmettin Erbakan University

Who can join

Adults 18 to 65, any sex, with Alveolar Bone Loss or Dental Implant. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial to test the effect of periimplant soft tissue phenotype in the participants with implant placed and at least 1 year after implant loading. The main questions it aims to answer are: 1. Is keratinized mucosal thickness (KMT) important in early marginal bone loss and peri implant health? 2. Is keratinized gingival width (KGW) important in early marginal bone loss and and peri implant health? The researchers plan to include 80 implants in the study. These 80 implants will be divided into 2 groups in 2 different ways according to their KMT and KGW on their buccal surfaces: KMT ≥2 mm are included in the adequate KMT, and those with KMT\<2 mm are in the insufficient KMT group. Those with KGW≥2 mm are adequate KGW, those with KGW\<2 mm are adequate KGW. The researchers will assess marginal bone loss around the implant using radiographs and collect peri-implant crevicular fluid (PICF) using paper strips. Another researchers will measure the Receptor Activator Of Nuclear Factor-Kappa B Ligand (RANKL), Osteoprotegerin (OPG), Tumor Necrosis Factor Alpha (TNF-α), MicroRNA-223 (MiRNA-223), MicroRNA-27a (MiRNA-27a) levels in the collected PICF. They will compare radiographic bone loss and biomarker levels in groups.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Association of Peri-Implant Keratinized Mucosa Width and Mucosal Thickness with Early Bone Loss: A Cross-Sectional Study.
Tastan Eroglu Z, Ozkan Sen D, Oncu E. · · 2024 · cited 5× · PMID 38610701 · DOI 10.3390/jcm13071936

Verify or expand the search:

Other recruiting trials for Alveolar Bone Loss

Currently open trials in the same condition.

NCT07508033 — Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing · Phase 1, PHASE2 · recruiting
NCT07375004 — Injectable PRF in Non-Surgical Periodontal Treatment · NA · active not recruiting
NCT07449806 — Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zo · NA · recruiting
NCT07419269 — Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation · NA · recruiting
NCT06887582 — Crestal Sinus Lifting in Periodontally-Compromised Patients Utilizing Autologous Dentin Graft · NA · active not recruiting

Other Necmettin Erbakan University trials

Trials by the same sponsor.

NCT07128407 — PMT-Based Radiation Safety Training for Nurses: Randomized Controlled Trial. · NA · active not recruiting
NCT07504770 — Surgical Glove Compression to Prevent Paclitaxel Neuropathy · NA · not yet recruiting
NCT07242807 — Minimally Invasive Prostate Interventions Registry (MIST Study) · not yet recruiting
NCT07442331 — The Effect of Game-Based Learning on Identifying Cognitive Distortions and Interpersonal Communication Competence in Nur · NA · completed
NCT07396038 — INTRAOPERATIVE BLADDER INJURY ASSESSMENT IN TURBT USING BICEP · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05640284 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Necmettin Erbakan University
Last refreshed: 25 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05640284.

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