NCT05638893 is a Phase 2, PHASE3 clinical trial of Metformin Hcl 500Mg Tab in Knee Osteoarthritis, sponsored by Tanta University.

Who is sponsoring NCT05638893?

NCT05638893 is sponsored by Tanta University.

What drugs are being tested in NCT05638893?

Interventions in NCT05638893: Placebo Tablet, Metformin Hcl 500Mg Tab.

What condition does NCT05638893 study?

NCT05638893 studies Knee Osteoarthritis.

Is NCT05638893 still recruiting?

NCT05638893 is currently completed. Last updated 7 December 2022.

Last reviewed 2022-12-07 · How we verify

NCT05638893

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients

Completed Phase 2, PHASE3 Last updated 7 December 2022

What this trial tests

Phase 2, PHASE3 trial testing Placebo Tablet in Knee Osteoarthritis in 50 participants. Completed in 15 April 2022.

Timeline

1 February 2021

Primary endpoint
12 March 2022

15 April 2022

Quick facts

Lead sponsor	Tanta University
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	50
Start date	1 February 2021
Primary completion	12 March 2022
Estimated completion	15 April 2022
Sites	1 location across Egypt

Drugs / interventions tested

Placebo Tablet
Metformin Hcl 500Mg Tab — full drug profile →

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Tanta University

Who can join

45 and older, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate the possible efficacy and safety of addition of metformin to celecoxib in patients with knee osteoarthritis.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system.
Mi B, Xiong Y, Knoedler S, Alfertshofer M, et al · · 2024 · cited 60× · PMID 39103328 · DOI 10.1038/s41413-024-00346-4
The involvement of signaling pathways in the pathogenesis of osteoarthritis: An update.
Fazio A, Di Martino A, Brunello M, Traina F, et al · · 2024 · cited 20× · PMID 39021400 · DOI 10.1016/j.jot.2024.06.002
Metformin as adjuvant therapy in obese knee osteoarthritis patients.
Aiad AAE, El-Haggar SM, El-Barbary AM, El-Afify DR. · · 2024 · cited 16× · PMID 38869746 · DOI 10.1007/s10787-024-01495-y
Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review).
Yang W, Yang Y, Wang Y, Gao Z, et al · · 2024 · cited 7× · PMID 38963023 · DOI 10.3892/ijmm.2024.5395
Exploring mitochondrial functions and dysfunctions in chondrocytes: toward the identification of novel therapies for osteoarthritis.
Danet L, Guicheux J, Boutet MA, Vinatier C. · · 2026 · PMID 42225637 · DOI 10.1038/s41413-026-00548-y

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Tanta University trials

Trials by the same sponsor.

NCT07398651 — Apremilast and Adalimumab in Psoriatic Arthritis Patients · NA · not yet recruiting
NCT06966856 — This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcti · Phase 3 · not yet recruiting
NCT07334197 — Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy · NA · not yet recruiting
NCT07498998 — Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome · NA · not yet recruiting
NCT07114250 — Comparative Study Between Spinal Anesthesia Versus General Anesthesia in Supine Percutaneous Nephrolithotomy Operation · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05638893 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tanta University
Last refreshed: 7 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05638893.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing