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NCT05634031
Imaging Coronary Microvascular Dysfunction (CMD) Study
NA trial testing PET imaging in Angina in 70 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Icahn School of Medicine at Mount Sinai |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 70 |
| Start date | 26 April 2023 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 March 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- PET imaging
- Coronary CT angiogram
- Functional Angiography
- Treadmill exercise stress study
Conditions studied
- Angina — all drugs for Angina →
- Non-obstructive Coronary Artery Disease — all drugs for Non-obstructive Coronary Artery Disease →
Sponsor
Icahn School of Medicine at Mount Sinai
Who can join
18 and older, any sex, with Angina or Non-obstructive Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million people in the United States alone, and 112 million people globally. Despite this, 4 in 10 patients undergoing elective coronary angiography for angina and ischemia do not have evidence of obstructive coronary artery disease (CAD). This condition of ischemia with no obstructive CAD (INOCA) is associated with high clinical and economic morbidity, as these patients have a higher rate of repeat procedures and hospitalizations, worse quality of life, future adverse cardiovascular events and frequent time missed from work. The overall objective of this study is to develop and validate a non-invasive algorithm for diagnosis and management of patients with INOCA and suspected microvascular dysfunction centered around cardiac PET MPI. A secondary goal of the study is to assess for improvement in patient symptoms, function and quality of life from PET-guided management of CMD in patients with INOCA. This study will take place at Mount Sinai Morningside in the PET and CTunit on the 3rd floor. The sub-study will occur at Mount Sinai Morningside Cath Lab on the 3rd floor. The study will enroll an estimated total of 70 subjects, 12 of which will also participate in the sub-study. The study is estimated to last 2 years.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Neuro-immune interactions in coronary microvascular disease: mechanisms and therapeutic prospect.
Ge Z, Wu G, Ma J, Ren S, et al · · 2025 · cited 1× · PMID 40948785 · DOI 10.3389/fimmu.2025.1631083
Verify or expand the search:
- PubMed search for NCT05634031
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05634031 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai
- Last refreshed: 16 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05634031.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing