NCT05624333: VD2O

Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O.

Completed NA Last updated 24 March 2023

What this trial tests

NA trial testing Vegan diet (intervention) in Sarcopenia in 38 participants. Completed in 13 February 2023.

Timeline

9 January 2023

Primary endpoint
13 February 2023

13 February 2023

Quick facts

Lead sponsor	Wageningen University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	supportive care
Enrollment	38
Start date	9 January 2023
Primary completion	13 February 2023
Estimated completion	13 February 2023
Sites	1 location across Netherlands

Drugs / interventions tested

• Vegan diet (intervention)
• Omnivorous diet (control)

Conditions studied

• Sarcopenia — all drugs for Sarcopenia →

Sponsor

Wageningen University

Who can join

Adults 65 to 79, any sex, with Sarcopenia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored. This is of particular importance in the older population, where sarcopenia is highly prevalent. The aim of this randomized controlled cross-over study is to investigate the short-term effect of a 10-day controlled vegan diet on daily muscle fractional synthesis rates in comparison to a 10-day controlled omnivorous diet in 35 community-dwelling older adults.

Participants will follow a fully controlled vegan diet, directly followed by a fully controlled omnivorous diet for 10 days, or vice versa. Researchers will compare the effect of the vegan diet to the effect of the omnivorous diet.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A Well-Balanced Vegan Diet Does not Compromise Daily Mixed Muscle Protein Synthesis Rates when Compared with an Omnivorous Diet in Active Older Adults: A Randomized Controlled Cross-Over Trial.
   Domić J, Pinckaers PJ, Grootswagers P, Siebelink E, et al · · 2025 · cited 9× · PMID 39732437 · DOI 10.1016/j.tjnut.2024.12.019