Last reviewed · How we verify
NCT05622188: HEATSTAR
The Detection of Heat Stress by Assessing Individual Body Responses to Heat (Heat Strain) in Young and Healthy Non-athlete Participants
trial testing Elevated ambient heat in Heat Stress in 23 participants. Completed in 10 February 2023.
31 January 2023
Quick facts
| Lead sponsor | ETH Zurich |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 23 |
| Start date | 2 November 2022 |
| Primary completion | 31 January 2023 |
| Estimated completion | 10 February 2023 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Elevated ambient heat
- Elevated relative humidity
- Exertion
Conditions studied
- Heat Stress — all drugs for Heat Stress →
Sponsor
ETH Zurich — full company profile →
Who can join
Adults 18 to 40, any sex, with Heat Stress. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
• This study investigates and compares the within and in-between variances of the body responses to different heat stressors in a controlled lab-setting. The participants will be exposed to different heat sources while a variety of physiological heat strain reactions such as heartrate, sweat rate, and core body temperature are recorded using on- and in-body devices. For the participant monitoring during the study, medical grade devices such as a certified ECG and a swallowable sensor-pill to continuously monitor the core body temperature will be applied. A one-for-all wearable device is additionally applied for physiological validation. Further, sweat will be collected to assess (i) the local sweat rate and (ii) the appearance of different heat stress associated molecular markers in this non-invasively collectable biofluid. As a secondary aim, a model will be developed that will enable to predict the different heat stress sources out of the heat strain measurements.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The molecular signature of heat stress in sweat reveals non-invasive biomarker candidates for health monitoring.
Brasier N, Niederberger C, Zanella M, Othman A, et al · · 2025 · cited 3× · PMID 40269247 · DOI 10.1038/s42003-025-08080-1
Verify or expand the search:
- PubMed search for NCT05622188
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Heat Stress
Currently open trials in the same condition.
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Other ETH Zurich trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05622188 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by ETH Zurich
- Last refreshed: 13 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05622188.
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