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NCT05609552
Biodistribution and Pharmacokinetics of Pretomanid in Tuberculosis Patients Using 18F-Pretomanid PET
trial testing 18F-Pretomanid PET/CT in Tuberculosis in 10 participants. Completed in 28 October 2025.
28 October 2025
Quick facts
| Lead sponsor | Johns Hopkins University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 22 May 2023 |
| Primary completion | 28 October 2025 |
| Estimated completion | 28 October 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- 18F-Pretomanid PET/CT
Conditions studied
- Tuberculosis — all drugs for Tuberculosis →
Sponsor
Johns Hopkins University
Who can join
18 and older, any sex, with Tuberculosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is an observational study that will examine the pretomanid pharmacokinetics (PK) in tuberculosis (TB) patients. Dynamic 18F-pretomanid PET/CT will be performed after intravenous injection of 18F-pretomanid to determine multi-compartment, noninvasive determination of pretomanid PK in TB patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.
Chen X, Arun B, Nino-Meza OJ, Sarhan MO, et al · · 2024 · cited 13× · PMID 39143055 · DOI 10.1038/s41467-024-50989-4
Verify or expand the search:
- PubMed search for NCT05609552
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05609552 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
- Last refreshed: 12 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05609552.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing