Who is sponsoring NCT05608057?

NCT05608057 is sponsored by Hams Hamed Abdelrahman.

What drugs are being tested in NCT05608057?

Interventions in NCT05608057: Vitamin C mesotherapy, Diode laser.

What condition does NCT05608057 study?

NCT05608057 studies Gingival Pigmentation.

Is NCT05608057 still recruiting?

NCT05608057 is currently completed. Last updated 27 April 2023.

Last reviewed 2023-04-27 · How we verify

NCT05608057

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vitamin C Mesotherapy Versus Diode Laser for the Management of Physiologic Gingival Pigmentation

Completed NA Last updated 27 April 2023

What this trial tests

NA trial testing Vitamin C mesotherapy in Gingival Pigmentation in 26 participants. Completed in 24 March 2023.

Timeline

22 October 2022

Primary endpoint
24 March 2023

24 March 2023

Quick facts

Lead sponsor	Hams Hamed Abdelrahman
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	26
Start date	22 October 2022
Primary completion	24 March 2023
Estimated completion	24 March 2023
Sites	1 location across Egypt

Drugs / interventions tested

Vitamin C mesotherapy
Diode laser

Conditions studied

Gingival Pigmentation — all drugs for Gingival Pigmentation →

Sponsor

Hams Hamed Abdelrahman — full company profile →

Who can join

Adults 18 to 45, any sex, with Gingival Pigmentation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Physiologic pigmentation affects the gingival esthetics. Laser ablation has been recently used as the most effective and reliable technique for gingival depigmentation. However, the high cost of laser technology limits its use in dental practice. Vitamin C/Ascorbic acid mesotherapy has been proposed as a minimally invasive, safe, cost-effective new modality of treatment.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Vitamin C mesotherapy versus diode laser for the esthetic management of physiologic gingival hyperpigmentation: a randomized clinical trial.
Esmat SA, El-Sayed NM, Fahmy RA. · · 2023 · cited 10× · PMID 37990224 · DOI 10.1186/s12903-023-03614-7
Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults.
Hu M, Gao Y, Xu J, Zhao J. · · 2025 · PMID 41088191 · DOI 10.1186/s12903-025-06953-9

Verify or expand the search:

Other trials of Vitamin C mesotherapy

Trials testing the same drug.

NCT07513727 — Vitamin C for Gingival Depigmentation · NA · recruiting

Other recruiting trials for Gingival Pigmentation

Currently open trials in the same condition.

NCT07359339 — Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation · NA · recruiting

Other Hams Hamed Abdelrahman trials

Trials by the same sponsor.

NCT07044882 — Hydrodynamic Piezoelectric Technique in Internal Sinus Lift · NA · not yet recruiting
NCT07082634 — Immediate Implant Placement Using the Socket Shield Technique in Maxillary Esthetic Zone · NA · not yet recruiting
NCT07044895 — Diode Laser Photocoagulation With Immediate Implant Placement · NA · not yet recruiting
NCT06759311 — Two Different Minimal Invasive Techniques in Caries Removal of Primary Teeth · NA · active not recruiting
NCT07103564 — The Effect of Local Melatonin Application Around Immediately Placed Implants in the Maxillary Premolar · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05608057 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hams Hamed Abdelrahman
Last refreshed: 27 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05608057.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing