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NCT05606536
The Impact of Intra-operative Fluid Infusion Rate on Microcirculation
NA trial testing Crystalloid Solutions in Fluid Therapy in 80 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | University Hospital Hradec Kralove |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 1 October 2022 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- Crystalloid Solutions — full drug profile →
Conditions studied
- Fluid Therapy — all drugs for Fluid Therapy →
- Microcirculation — all drugs for Microcirculation →
- Hemodilution — all drugs for Hemodilution →
Sponsor
University Hospital Hradec Kralove
Who can join
18 and older, any sex, with Fluid Therapy or Microcirculation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. For elective surgery that is not associated with higher blood loss and a long period of preoperative fasting, including fluids IFT is dosed to cover the basal daily need for fluids. However, it is not clear whether this fluid dose is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG). EG binds a significant amount of plasma, which is released during EG destruction and causes relative hemodilution. Isovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected. However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05606536
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Related trials
Other trials of Crystalloid Solutions
Trials testing the same drug.
- NCT04681638 — Plasma Resuscitation Without Lung Injury · Phase 4 · terminated
- NCT05079269 — Pre-op Fluid Study · NA · active not recruiting
- NCT05358912 — Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock · Phase 4 · completed
- NCT04600271 — Acute Renal Injury After Major Elective Non-Cardiac Surgery · completed
- NCT03157479 — Intraoperative Protective Ventilation for Obese Patients Undergoing Gynaecological Laparoscopic Surgery · NA · completed
Other recruiting trials for Fluid Therapy
Currently open trials in the same condition.
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- NCT06396884 — Hemodynamic Optimization During Spinal Anesthesia in the Elderly · recruiting
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Other University Hospital Hradec Kralove trials
Trials by the same sponsor.
- NCT07415655 — Modulation of Cerebral Ischemia by Albumin · Phase 2 · not yet recruiting
- NCT03644641 — The Influence of Prone Position for Spinal Surgery on Visual Acuity · NA · not yet recruiting
- NCT06894927 — Hearing Screening in Adults Over 50 Years Old · NA · enrolling by invitation
- NCT05399602 — The Role of Neurofilament Light (NfL) in Patients With Hydrocephalus · NA · completed
- NCT06083233 — Role of Brain Specific Biomarkers in Hydrocephalus · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05606536 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital Hradec Kralove
- Last refreshed: 27 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05606536.
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