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NCT07255469: METAFRIC
Metabolic Fluid Responsiveness in Children
trial in Circulatory Failure / Shock State in 110 participants. Currently enrolling.
21 March 2027
Quick facts
| Lead sponsor | University Hospital, Bordeaux |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 110 |
| Start date | 21 March 2025 |
| Primary completion | 21 March 2027 |
| Estimated completion | 18 April 2027 |
| Sites | 8 locations across France |
Conditions studied
- Circulatory Failure / Shock State — all drugs for Circulatory Failure / Shock State →
- Fluid Therapy — all drugs for Fluid Therapy →
Sponsor
University Hospital, Bordeaux
Who can join
Adults 0 Days to 15, any sex, with Circulatory Failure / Shock State or Fluid Therapy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07255469
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07255469 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bordeaux
- Last refreshed: 1 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07255469.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing