Adults 18 to 35, any sex, with Executive Function. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Percentage of the Trials That the Participant Chooses to Perform the Hard TaskPrimary· 2 hours during the 1st intervention and 2 hours during the 2nd intervention
In the Expenditure of Effort for Reward Task, participants are faced with a decision on every trial: to choose an easy task with a low effort exertion for a chance at winning a low amount of money and a hard task with a high effort exertion for a chance at winning a greater amount of money. The incentive for the high effort exertion is changed on each trial and the participant gets physically tired from repeated effort exertion. Goal-directed behavior was calculated as the percentage of trials in which the participant decides to perform the most difficult effort exertion task in the Expenditur
Group
Value
95% CI
Delta-beta TMS to Lateral Prefrontal Cortex
33.2
± 22.2
Theta-gamma TMS to Lateral Prefrontal Cortex
32.9
± 20.1
Arrhythmic TMS to Lateral Prefrontal Cortex
33.6
± 21.0
Delta-beta TMS to Medial Prefrontal Cortex
37.1
± 21.6
Theta-gamma TMS to Medial Prefrontal Cortex
37.1
± 21.9
Arrhythmic TMS to Medial Prefrontal Cortex
37.6
± 19.5
Coupling Strength Between Low-frequency Prefrontal Signals and High-frequency Posterior SignalsSecondary· 2 hours during the 1st intervention and 2 hours during the 2nd intervention
Phase-amplitude coupling strength is calculated using the mean vector length metric between low-frequency activity in prefrontal electrodes and high-frequency activity in motor electrodes. A Z-score indicates the number of standard deviations away from the mean of distribution generated by randomly time-shifting the data. A Z-score of 0 is equal to the mean coupling strength of random data. Higher values are greater coupling strength. Positive values (\> 1) indicate increased prefrontal control over the motor cortex, which is found in healthy individuals during decision-making.
Group
Value
95% CI
Delta-beta TMS to Lateral Prefrontal Cortex
0.416
± 1.073
Theta-gamma TMS to Lateral Prefrontal Cortex
0.008
± 1.214
Arrhythmic TMS to Lateral Prefrontal Cortex
0.308
± 1.112
Delta-beta TMS to Medial Prefrontal Cortex
-0.051
± 1.241
Theta-gamma TMS to Medial Prefrontal Cortex
-0.094
± 0.850
Arrhythmic TMS to Medial Prefrontal Cortex
0.274
± 1.027
Adverse events — posted to ClinicalTrials.gov
Time frame: Adverse events were monitored during the first and second intervention, a total of four hours across 1 week.
Reporting threshold: 0%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
The purpose of this clinical trial is to investigate the causal role that frontostriatal circuitry plays in goal-directed behavior. The participants will perform a reward-based decision-making task. During the task, cross-frequency patterned rhythmic transcranial magnetic stimulation (TMS) will be delivered at delta-beta frequency, a control-frequency, or an active sham to either the dorsolateral or medial prefrontal cortex (PFC). Electroencephalography will be collected concurrent with stimulation. Structural and functional magnetic resonance imaging (MRI) will be collected during performance of the reward-based decision-making task to localize the stimulation targets.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of North Carolina, Chapel Hill
Last refreshed: 17 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05593965.