Who is sponsoring NCT05590676?

NCT05590676 is sponsored by The Hospital for Sick Children.

What drugs are being tested in NCT05590676?

Interventions in NCT05590676: Metformin Hydrochloride.

What condition does NCT05590676 study?

NCT05590676 studies Hypoxic Ischemic Encephalopathy of Newborn, Premature Birth.

Is NCT05590676 still recruiting?

NCT05590676 is currently terminated. Last updated 7 March 2024.

Last reviewed 2024-03-07 · How we verify

NCT05590676

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Metformin Treatment in Infants After Perinatal Brain Injury

Terminated Phase 1 Last updated 7 March 2024

What this trial tests

Phase 1 trial testing Metformin Hydrochloride in Hypoxic Ischemic Encephalopathy of Newborn in 1 participant. Terminated before completion.

Timeline

2 May 2023

Primary endpoint
22 February 2024

22 February 2024

Quick facts

Lead sponsor	The Hospital for Sick Children
Phase	Phase 1
Status	Terminated
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	1
Start date	2 May 2023
Primary completion	22 February 2024
Estimated completion	22 February 2024
Sites	1 location across Canada

Drugs / interventions tested

Metformin Hydrochloride — full drug profile →

Conditions studied

Hypoxic Ischemic Encephalopathy of Newborn — all drugs for Hypoxic Ischemic Encephalopathy of Newborn →
Premature Birth — all drugs for Premature Birth →

Sponsor

The Hospital for Sick Children

Who can join

Under 3 Months, any sex, with Hypoxic Ischemic Encephalopathy of Newborn or Premature Birth. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A phase I study to test the feasibility and safety of treatment with metformin in infants affected by hypoxic ischemic encephalopathy (HIE) or prematurity-related brain injury

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy.
Ranjan AK, Gulati A. · · 2023 · cited 41× · PMID 37892791 · DOI 10.3390/jcm12206653
Metformin Repurposing in Neurological Disorders: A Clinical Trial Landscape.
R Y, Sharma S, C M, Rangari GM, et al · · 2026 · PMID 41930282 · DOI 10.1177/09727531261421807
Pharmacological Therapies for Consequences of Perinatal Hypoxic-Ischemic Brain Injury: Where Are We Now?
Gebala P, Janowska J, Sypecka J. · · 2025 · PMID 41155490 · DOI 10.3390/ijms262010200

Verify or expand the search:

Other trials of Metformin Hydrochloride

Trials testing the same drug.

NCT07380841 — Metformin vs Inositol vs Diet vs Combination Therapy in PCOS · NA · completed
NCT06899061 — Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saru · Phase 1 · active not recruiting
NCT06920056 — A Study of BGM0504 in Overweight or Obese Participants · Phase 1 · completed
NCT06638671 — Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity · Phase 4 · recruiting
NCT05828303 — A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastat · Phase 1 · withdrawn

Other recruiting trials for Hypoxic Ischemic Encephalopathy of Newborn

Currently open trials in the same condition.

NCT06762795 — The HIEnome Study: Genome Sequencing for Perinatal HIE · NA · recruiting
NCT06747260 — Feasibility and Safety of Intranasally Administered Breast Milk in HIE · EARLY_PHASE1 · recruiting
NCT06563687 — Continuous Glucose Monitoring in HIE · NA · recruiting
NCT06522581 — Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy · Phase 1 · recruiting

Other The Hospital for Sick Children trials

Trials by the same sponsor.

NCT07454681 — MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure . · not yet recruiting
NCT07452575 — 3D Ultrasound in Hemophilic Ankles · NA · not yet recruiting
NCT07508826 — AI-assisted Endotracheal Intubation · NA · not yet recruiting
NCT07345819 — Dexamethasone vs. Placebo in Children and Youth Hospitalized for Orbital Cellulitis · NA · not yet recruiting
NCT07497178 — MRgFUS for Childhood Epilepsy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05590676 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Hospital for Sick Children
Last refreshed: 7 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05590676.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing