NCT05586347

Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery

Completed NA Last updated 19 October 2022

What this trial tests

NA trial testing Nicardipine in Coronary Artery Bypass Grafting in 64 participants. Completed in 30 September 2022.

Timeline

22 April 2022

Primary endpoint
22 September 2022

30 September 2022

Quick facts

Lead sponsor	Nanjing First Hospital, Nanjing Medical University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	64
Start date	22 April 2022
Primary completion	22 September 2022
Estimated completion	30 September 2022
Sites	1 location across China

Drugs / interventions tested

• Nicardipine (NICARDIPINE) — full drug profile →
• normal saline

Conditions studied

• Coronary Artery Bypass Grafting — all drugs for Coronary Artery Bypass Grafting →
• Cardiopulmonary Bypass — all drugs for Cardiopulmonary Bypass →

Sponsor

Nanjing First Hospital, Nanjing Medical University

Who can join

Adults 60 to 80, any sex, with Coronary Artery Bypass Grafting or Cardiopulmonary Bypass. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery, mainly manifested as mental confusion, anxiety, personality change and memory impairment, which seriously affects the quality of life of patients after surgery.Attention should be paid to the protection of neurological function in patients undergoing cardiac surgery during perioperative period.Nicardipine can selectively act on coronary arteries and cerebral vessels, increase coronary artery and cerebral blood flow, relieve coronary heart disease angina pectoris, protect brain tissue.The cerebral protective effect of nicardipine on cardiovascular surgery under CPB deserves further clinical study.About 15-20% of cardiac output (CO) in healthy adults is allocated to the brain , and cerebral blood flow is supplied by bilateral internal carotid artery (ICA) and vertebral artery (VA), among which ICA provides about 70%-80% of cerebral perfusion flow .However, the location of the internal carotid artery is superficial, the anatomical variation is less, and the ultrasonic Doppler technique is portable and simple to measure. It may be of certain clinical value to use the ultrasonic detection technology to quickly evaluate the cerebral perfusion during the perioperative period, and to early detect and avoid the intraoperative brain function injury.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.