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NCT06798714: CAFE
The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery
Phase 4 trial testing NSAID in Coronary Artery Disease in 140 participants. Currently enrolling.
20 July 2025
Quick facts
| Lead sponsor | Tomsk Cardiology Research Institute |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 140 |
| Start date | 20 January 2025 |
| Primary completion | 20 July 2025 |
| Estimated completion | 20 February 2026 |
| Sites | 1 location across Russia |
Drugs / interventions tested
- NSAID (NSAID) — full drug profile →
- Colchicine 0.5 MG — full drug profile →
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Coronary Artery Bypass Grafting — all drugs for Coronary Artery Bypass Grafting →
- Colchicine — all drugs for Colchicine →
Sponsor
Tomsk Cardiology Research Institute
Who can join
18 and older, any sex, with Coronary Artery Disease or Atrial Fibrillation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Development of a new comprehensive method for perioperative prevention of atrial fibrillation paroxysms in cardiac surgery patients at the hospital stage. It is planned to recruit 70 patients who will undergo pericardial fenestration during the operation using the original technique during coronary artery bypass grafting (Patent No. 2647626 C1 Russian Federation), and will be prescribed colchicine (the drug "Colchicum-dispert") in the perioperative period in order to prevent the development of paroxysms of atrial fibrillation in the postoperative period, and 70 cardiac surgery patients operated on using the standard technique (without performing the pericardial fenestration procedure intraoperatively), receiving non-steroidal anti-inflammatory drugs in the postoperative period.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Combined Approach to the Prevention of Postoperative Atrial Fibrillation in Cardiac Surgery.
Diakova ML, Kuznetsov MS, Vechersky YY, Kim EB, et al · · 2025 · PMID 40868251 · DOI 10.3390/biomedicines13081999
Verify or expand the search:
- PubMed search for NCT06798714
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Tomsk Cardiology Research Institute trials
Trials by the same sponsor.
- NCT07071857 — Coronary Artery Bypass Grafting With Ascending Aortic Replacement · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06798714 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tomsk Cardiology Research Institute
- Last refreshed: 9 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06798714.
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