Last reviewed · How we verify
NCT05585216
The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq
NA trial testing platelet-rich plasma in Platelet-rich Plasma in 120 participants. Completed in 1 October 2021.
31 August 2021
Quick facts
| Lead sponsor | Hebei Medical University Third Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 1 January 2021 |
| Primary completion | 31 August 2021 |
| Estimated completion | 1 October 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- platelet-rich plasma
Conditions studied
- Platelet-rich Plasma — all drugs for Platelet-rich Plasma →
- Physical Exercise — all drugs for Physical Exercise →
- Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
Sponsor
Hebei Medical University Third Hospital
Who can join
Adults 40 to 80, any sex, with Platelet-rich Plasma or Physical Exercise. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objective. In this study, the investigators aimed to investigate the efficacy of combined a single platelet-rich plasma (PRP) and physical exercise (leg swing and quadriceps strengthening exercise) versus PRP and hyaluronic acid (HA) combination therapy. Methods. One hundred and six patients with grade Ⅱ-Ⅲ Knee osteoarthritis (KOA) according to the Kellgren-Lawrence classification were randomly divided into intra-articular injection of PRP combined with leg swing and quadriceps strengthening exercise (group A) and intra-articular combination injections of PRP and HA (group B). Patients in group A received twice intra-articular injection of PRP (2 ml, 2 weeks apart) and regular leg swing and quadriceps strengthening exercise for 3 months. Patients in group B received twice intra-articular combination injections of PRP (2 ml) and HA (2 ml) every 2 weeks. The primary outcome measures were Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities (WOMAC) score. The second outcomes included single leg stance test (SLS) and functional activity by 2 minutes walking test (2MWT) and time up and go test (TUGT). All outcomes were evaluated at baseline and after 1,3,6, and 12 months.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The efficacy of the leg swing and quadriceps strengthening exercises versus platelet-rich plasma and hyaluronic acid combination therapy for knee osteoarthritis: A retrospective comparative study.
Ma C, Li X, Pan Y, Tian H, et al · · 2023 · cited 1× · PMID 37713885 · DOI 10.1097/md.0000000000035238
Verify or expand the search:
- PubMed search for NCT05585216
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of platelet-rich plasma
Trials testing the same drug.
- NCT07151703 — Topical Versus Injection PRP for Olfactory Dysfunction · Phase 3 · not yet recruiting
- NCT07107399 — Therapeutic Effect of Microfragmented Adipose Tissue (Lipogems) Injection on Maximum Interincisal Opening Versus Injecta · Phase 2, PHASE3 · not yet recruiting
- NCT06896747 — Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study · Phase 1, PHASE2 · recruiting
- NCT04264000 — Platelet-rich Plasma Injection for Ulnar Neuropathy at Elbow · NA · completed
- NCT03211650 — Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis · Phase 4 · completed
Other recruiting trials for Platelet-rich Plasma
Currently open trials in the same condition.
- NCT06492213 — The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for Infraorbital Neuralgia · recruiting
Other Hebei Medical University Third Hospital trials
Trials by the same sponsor.
- NCT06272656 — Evaluation of AKR1B10 as a New Marker for Interventional Therapy of Hepatocellular Carcinoma · recruiting
- NCT06238804 — Characteristic Analysis and Surgical Exploration for Acetabular Roof Fractures: Multicenter Retrospective Cohort Study · withdrawn
- NCT05661227 — Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion · NA · unknown
- NCT05030259 — The Research About the ACS After Femoropopliteal Arterial Injuries · recruiting
- NCT04891458 — Effect of Intraoperative Sedation on PND in Elderly Patients · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05585216 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hebei Medical University Third Hospital
- Last refreshed: 20 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05585216.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing