Last reviewed · How we verify
NCT05582811
Effect of Riocigaut on Cerebral Vasodilation and Headache Induction in Healthy Volunteers
NA trial testing Dose Riociguat 2,5 or 5mg in Headache in 15 participants. Completed in 1 June 2023.
1 June 2023
Quick facts
| Lead sponsor | Danish Headache Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 15 |
| Start date | 26 October 2022 |
| Primary completion | 1 June 2023 |
| Estimated completion | 1 June 2023 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Dose Riociguat 2,5 or 5mg — full drug profile →
- Riociguat (RIOCIGUAT) — full drug profile →
- Placebo
Conditions studied
- Headache — all drugs for Headache →
Sponsor
Danish Headache Center — full company profile →
Who can join
Adults 18 to 45, any sex, with Headache. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This double-blind, randomized, placebo-controlled cross-over clinical trial aims to investigate the effects of riocigaut on cerebral arteries and headache inducing properties in healthy volunteers.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Soluble guanylate cyclase induces cranial vasodilation and headache in adults: a randomized trial.
Rasmussen NB, Christensen CE, Ashina H, Amin FM, et al · · 2025 · cited 1× · PMID 41322201 · DOI 10.1093/braincomms/fcaf436
Verify or expand the search:
- PubMed search for NCT05582811
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Danish Headache Center trials
Trials by the same sponsor.
- NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
- NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
- NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
- NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
- NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05582811 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
- Last refreshed: 5 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05582811.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing