NCT05575323 (BLEND) is a NA clinical trial of Same-day SBRT and spinal surgery in Spinal Metastases, sponsored by UMC Utrecht.

Who is sponsoring NCT05575323?

NCT05575323 is sponsored by UMC Utrecht.

What drugs are being tested in NCT05575323?

Interventions in NCT05575323: Same-day SBRT and spinal surgery, Standard of care.

What condition does NCT05575323 study?

NCT05575323 studies Spinal Metastases.

Is NCT05575323 still recruiting?

NCT05575323 is currently recruiting now. Last updated 3 April 2025.

Last reviewed 2025-04-03 · How we verify

NCT05575323: BLEND

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases

Recruiting now NA Last updated 3 April 2025

What this trial tests

NA trial testing Same-day SBRT and spinal surgery in Spinal Metastases in 100 participants. Currently enrolling.

Timeline

15 October 2022

Primary endpoint
30 June 2026

30 June 2027

Quick facts

Lead sponsor	UMC Utrecht
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	100
Start date	15 October 2022
Primary completion	30 June 2026
Estimated completion	30 June 2027
Sites	1 location across Netherlands

Drugs / interventions tested

Same-day SBRT and spinal surgery
Standard of care

Conditions studied

Spinal Metastases — all drugs for Spinal Metastases →

Sponsor

UMC Utrecht — full company profile →

Who can join

18 and older, any sex, with Spinal Metastases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The BLEND RCT aims to evaluate the (cost-)effectiveness of same-day SBRT and surgical stabilization with or without decompression for the treatment of symptomatic, unstable spinal metastases on physical functioning four weeks after the start of treatment, compared with the standard of care (surgery followed by radiotherapy as soon as the wound healed sufficiently).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Stereotactic Body radiotherapy and pedicLE screw fixatioN During one hospital visit for patients with symptomatic unstable spinal metastases: a randomized trial (BLEND RCT) using the Trials within Cohorts (TwiCs) design.
Huele EH, van der Velden JM, Kasperts N, Eppinga WSC, et al · · 2023 · cited 6× · PMID 37143158 · DOI 10.1186/s13063-023-07315-y
Radiotherapy and surgery: can this combination be further optimized for patients with metastatic spine disease?
Amelink JJGJ, Bindels BJJ, Kasperts N, MacDonald SM, et al · · 2025 · cited 5× · PMID 39832131 · DOI 10.1093/oncolo/oyae359

Verify or expand the search:

Other recruiting trials for Spinal Metastases

Currently open trials in the same condition.

NCT06548061 — D20054;LITT for Spine Tumors · NA · recruiting
NCT06244264 — The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis · NA · recruiting
NCT06120426 — En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor · recruiting
NCT07429422 — SBRT Technique Implementation for Spinal Metastases Irradiation · NA · recruiting
NCT04863612 — SBRT in the Management of Solid Spinal Metastases · recruiting

Other UMC Utrecht trials

Trials by the same sponsor.

NCT07512336 — A Randomized Intra-Patient Controlled Trial of MagnetOs™ Putty vs Autograft in Instrumented Posterolateral Spinal Fusion · NA · not yet recruiting
NCT07485985 — Coronary Sinus Reducer Therapy for Persisting Angina · NA · not yet recruiting
NCT07449052 — Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease · NA · not yet recruiting
NCT05375708 — Systemic Therapy in Combination with Stereotactic Radiotherapy in Patients with Metastatic Colorectal Cancer Up to 10 Me · Phase 2 · suspended
NCT06898541 — Coronary Sinus Reducer in Coronary Microvascular Disease · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05575323 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by UMC Utrecht
Last refreshed: 3 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05575323.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing