Last reviewed · How we verify
NCT05573451: CANNES
Comparison of the Accuracy of US, MRI and PET/CT in the Assessment of LNs in Cervical Cancer.
trial testing ultrasound - transvaginal/transrectal + transabdominal in Lymph Node Metastasis in 91 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2023
Quick facts
| Lead sponsor | General University Hospital, Prague |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 91 |
| Start date | 20 January 2021 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- ultrasound - transvaginal/transrectal + transabdominal
Conditions studied
- Lymph Node Metastasis — all drugs for Lymph Node Metastasis →
- Cervical Cancer — all drugs for Cervical Cancer →
Sponsor
General University Hospital, Prague
Who can join
Adults 18 to 80, female only, with Lymph Node Metastasis or Cervical Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lymph node involvement is the most important negative prognostic factor in cervical cancer. Reliable preoperative lymph node assessment is of utmost importance to tailor the treatment. According to the current European guidelines local extent of the disease can be assessed by magnetic resonance imaging (MRI) or by ultrasound (US), if performed by properly trained sonographer. Positron emission tomography combined with computed tomography (PET/CT) is used as a reference standard for preoperative evaluation of lymph nodes. Another technique to assess nodes combining morphological and functional characteristics is diffusion-weighted MRI (DW/MRI). While US is considered the adequate alternative to MRI in local staging of cervical cancer, there is no relevant evidence of diagnostic performace of US in nodal assessment. However, retrospective analysis of diagnostic accuracy of US from our site brought promising results. Furthermore, there are no trials prospectively investigating these three imaging methods in the same study population. The CANNES study is a prospective multicenter trial comparing diagnostic accuracy of US, PET/CT and DW/MRI in preoperative assessment of pelvic lymph nodes in cervical cancer. The study is designed to establish new standard in preoperative assessment of pelvic lymph nodes in patients with cervical cancer. Ninety-one patients will be enrolled into the study within 36 months and each of them will undergo all three imaging methods. To avoid a bias all imaging examinations will be conducted independently and blinded among sonographers, radiologists and nuclear medicine physicians. By contrast, each surgeon will have all reports from imaging available before procedure to be used as a navigation. Surgical procedures will include sentinel lymph node biopsy, debulking/sampling or systematic dissection of pelvic nodes following current European guidelines.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Staging by imaging in gynecologic cancer and the role of ultrasound: an update of European joint consensus statements.
Fischerova D, Smet C, Scovazzi U, Sousa DN, et al · · 2024 · cited 23× · PMID 38438175 · DOI 10.1136/ijgc-2023-004609 -
Prospective comparison of diagnostic accuracy of ultrasound, PET/CT and DW-MRI for preoperative assessment of pelvic lymph nodes in cervical cancer patients: results of the CANNES trial.
Frühauf F, Fischerová D, Moro F, Kocián R, et al · · 2026 · PMID 42178785 · DOI 10.1002/uog.70241
Verify or expand the search:
- PubMed search for NCT05573451
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Lymph Node Metastasis
Currently open trials in the same condition.
- NCT06829147 — A Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma(NPC) · recruiting
- NCT06623266 — Neck Observation or Elective Neck Dissection in CT1N0M0 OSCC · NA · recruiting
- NCT06621823 — Image-guided Ultrasound Robotic Intraoperative Evaluation of Lymph-nodes Status in Gynecological Malignancies · NA · recruiting
- NCT06264167 — NODE (groiN ultrasOunD cancEr) · NA · recruiting
- NCT07050576 — Lymph Node Metastasis in Early Esophageal Squamous Cell Carcinoma · recruiting
Other General University Hospital, Prague trials
Trials by the same sponsor.
- NCT07493928 — HPV After chemoRadioTherapy · recruiting
- NCT07495410 — Anderson-Fabry Disease Fitness Improvement Training: A-FAD-FIT · NA · enrolling by invitation
- NCT06942533 — Effect of Visual Feedback From the SpiroGym Mobile Application · NA · recruiting
- NCT06789978 — Rapid Prehospital ACcess to ECPR in Prague · NA · recruiting
- NCT06585332 — Handgrip and Respiratory Dysfunction in HD Patients. · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05573451 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by General University Hospital, Prague
- Last refreshed: 25 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05573451.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing