Last reviewed · How we verify
NCT06585332
Handgrip and Respiratory Dysfunction in HD Patients.
trial testing Assessment of respiratory paramenters (Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow)) in Huntington Disease in 70 participants. Completed in 31 October 2024.
31 October 2024
Quick facts
| Lead sponsor | General University Hospital, Prague |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 70 |
| Start date | 1 April 2024 |
| Primary completion | 31 October 2024 |
| Estimated completion | 31 October 2024 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- Assessment of respiratory paramenters (Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow))
Conditions studied
- Huntington Disease — all drugs for Huntington Disease →
Sponsor
General University Hospital, Prague
Who can join
Adults 18 to 80, any sex, with Huntington Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hereditary neurodegenerative diagnosis of Huntington's disease (HD) is associated with a progressive deterioration of the respiratory system function . This fact contributes strongly to the increased risk of aspiration pneumonia as a primary cause of death in people with HD. But regularly objective monitoring of the airway system condition is in common clinical practice almost impossible for high time requirements and the need for specialized expensive devices . This drives the need for a simpler and more cost-effective screening tool. In recent years published studies, working with all ages and genders, show correlation between hand grip strength (HGS) and respiratory parameters. As a second simple screening tool, we chose a short questionnaire called the Index of pulmonary dysfunction.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Huntington's disease clinical trials update: March 2025.
Farag M, Tabrizi SJ, Wild EJ. · · 2025 · cited 7× · PMID 40302443 · DOI 10.1177/18796397251337000 -
Handgrip strength and the Index of pulmonary dysfunction: Practical screening tools for cough dysfunction in huntington's disease.
Konvalinkova R, Srp M, Doleckova K, Capek V, et al · · 2026 · PMID 41332279 · DOI 10.1177/18796397251385607 -
Huntington's disease clinical trials update: October 2025.
Farag M, Tabrizi SJ, Wild EJ. · · 2026 · PMID 41295902 · DOI 10.1177/18796397251399751
Verify or expand the search:
- PubMed search for NCT06585332
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other General University Hospital, Prague trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06585332 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by General University Hospital, Prague
- Last refreshed: 17 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06585332.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing