Last reviewed · How we verify
NCT05555498: VitRo
Virtual Reality for Anxiety and Pain Management During Oocyte Retrieval in IVF/ICSI Treatment
NA trial testing Virtual Reality glasses in IVF in 112 participants. Status unknown.
1 June 2024
Quick facts
| Lead sponsor | Amsterdam UMC, location VUmc |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 112 |
| Start date | 1 November 2022 |
| Primary completion | 1 June 2024 |
| Estimated completion | 1 May 2025 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Virtual Reality glasses
Conditions studied
- IVF — all drugs for IVF →
- Procedural Pain — all drugs for Procedural Pain →
- Procedural Anxiety — all drugs for Procedural Anxiety →
Sponsor
Amsterdam UMC, location VUmc — full company profile →
Who can join
Adults 18 to 43, any sex, with IVF or Procedural Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Despite current anxiety and pain management during oocyte retrieval in IVF/ICSI treatment by conscious sedation, oocyte retrieval often remains painful and stressful for patients. An average pain score of 6.0 (expressed using VAS) and stress score of 41.63 (using STAI-S) were reported by previous researches. Previous research showed there might be a negative correlation between anxiety experienced in IVF/ICSI treatment, and ongoing pregnancy rate. Other researches nuance this. In addition, conscious sedation can give a variety of side effects such as apnea and respiratory depression. The appliance of Virtual Reality is increasingly researched, in a variety of procedures. Previous researches showed that Virtual Reality was effective in the reduction of anxiety and pain experienced, also in the field of Gynaecology and Obstetrics. We hypothesized that Virtual Reality can aid in the reduction of anxiety and pain experienced during oocyte retrieval in IVF/ICSI treatment. We also aim to find a definitive answer on the question whether anxiety during IVF/ICSI treatment can negatively influence ongoing pregnancy rates.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
No anxiety or pain reduction by Virtual Reality during oocyte retrieval in IVF/ICSI treatment: results of a randomized controlled trial.
van Haaps AP, Schreurs AMF, Rosielle K, Mijatovic V, et al · · 2026 · PMID 41057042 · DOI 10.1093/humrep/deaf193
Verify or expand the search:
- PubMed search for NCT05555498
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05555498 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Amsterdam UMC, location VUmc
- Last refreshed: 27 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05555498.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing