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NCT05554523: PAISKINTONE
How Does Skin Tone Affect Quantitative Photoacoustic Imaging
trial testing Photoacoustic imaging in Vitiligo in 42 participants. Status unknown.
15 April 2023
Quick facts
| Lead sponsor | University of Cambridge |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 42 |
| Start date | 1 October 2022 |
| Primary completion | 15 April 2023 |
| Estimated completion | 15 October 2023 |
Drugs / interventions tested
- Photoacoustic imaging
Conditions studied
- Vitiligo — all drugs for Vitiligo →
- Skin Abnormalities — all drugs for Skin Abnormalities →
Sponsor
University of Cambridge
Who can join
Adults 20 to 70, any sex, with Vitiligo or Skin Abnormalities. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Photoacoustic imaging (PAI) is an emerging method which combines light and ultrasound to assess the blood content and oxygenation of the body. Light is absorbed by the blood, leading to the generation of ultrasound, from which the levels of oxygen can be derived. This high sensitivity to blood has seen it applied in multiple clinical trials for the assessment of a number of conditions including breast cancer assessment. However, the accuracy of the measurements and image quality is known to decrease as you look deeper into the body because light intensity decreases. Melanin in the skin is known to absorb light very strongly and so there is considerable concern that this may bias measurements made in people with darker skin tones compared to those with lighter skin tones. In this pilot study, we intend to recruit volunteers with a wide range of skin tones and vitiligo. We will scan a number of blood vessels and muscles using PAI and evaluate the photoacoustic measurements of blood content and oxygenation to identify, and ultimately correct for, biases in advance of further clinical studies.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The confounding effects of skin colour in photoacoustic imaging
Else TR, Loreno C, Groves A, Cox BT, et al · · 2025 · cited 1× · DOI 10.1101/2025.03.28.25324605
Verify or expand the search:
- PubMed search for NCT05554523
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Vitiligo
Currently open trials in the same condition.
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- NCT07532330 — Tyrosine Vs Tacrolimus With NB-UVB in Vitiligo · NA · active not recruiting
- NCT07357870 — A Proof of Concept, Phase 1 Study of CGB-600 for the Topical Treatment of Non-Segmented Facial Vitiligo · Phase 1 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05554523 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Cambridge
- Last refreshed: 26 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05554523.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing