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NCT05550935
Physiological Effects of High-flow Nasal Cannula During Exercise
NA trial testing High-flow Nasal Cannula in Healthy Volunteers in 14 participants. Completed in 29 January 2023.
13 September 2022
Quick facts
| Lead sponsor | Pontificia Universidad Catolica de Chile |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 14 |
| Start date | 25 July 2022 |
| Primary completion | 13 September 2022 |
| Estimated completion | 29 January 2023 |
| Sites | 1 location across Chile |
Drugs / interventions tested
- High-flow Nasal Cannula
Conditions studied
- Healthy Volunteers — all drugs for Healthy Volunteers →
Sponsor
Pontificia Universidad Catolica de Chile — full company profile →
Who can join
Adults 18 to 45, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The high-flow nasal cannula (HFNC) has increased its evidence in patients during pulmonary rehabilitation. These studies hypothesize that the physiological effects of HFNC (positive expiratory pressure, anatomical dead space lavage, thermo-humidification) lead to an increase in exercise time. This is believed to be due to improvements that the device can generate in the respiratory system and muscles. However, the physiological effects of HFNC on respiratory effort and distribution of pulmonary ventilation during exercise are unknown. The aim of this study is to determine the acute effect of high flow nasal cannula on the distribution of pulmonary ventilation and respiratory effort during physical exercise in healthy subjects.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Physiological effects of high-flow nasal cannula during sustained high-intensity exercise in healthy volunteers: a randomised crossover trial.
Moya-Gallardo E, Garcia-Valdés P, Marambio-Coloma C, Gutierrez-Escobar C, et al · · 2025 · cited 2× · PMID 39902265 · DOI 10.1183/23120541.00482-2024
Verify or expand the search:
- PubMed search for NCT05550935
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Pontificia Universidad Catolica de Chile trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05550935 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pontificia Universidad Catolica de Chile
- Last refreshed: 7 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05550935.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing