NCT05537077 is a NA clinical trial of Prolotherapy in Knee Osteoarthritis, sponsored by Turkish League Against Rheumatism.

Who is sponsoring NCT05537077?

NCT05537077 is sponsored by Turkish League Against Rheumatism.

What drugs are being tested in NCT05537077?

Interventions in NCT05537077: Prolotherapy, Home based exercise program, Hotpack therapy.

What condition does NCT05537077 study?

NCT05537077 studies Knee Osteoarthritis.

Is NCT05537077 still recruiting?

NCT05537077 is currently completed. Last updated 13 September 2022.

Last reviewed 2022-09-13 · How we verify

NCT05537077

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Different Concentrations of Dextrose Prolotherapy Treatment in Knee Osteoartritis

Completed NA Last updated 13 September 2022

What this trial tests

NA trial testing Prolotherapy in Knee Osteoarthritis in 128 participants. Completed in 1 March 2021.

Timeline

1 March 2020

Primary endpoint
1 March 2021

1 March 2021

Quick facts

Lead sponsor	Turkish League Against Rheumatism
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	128
Start date	1 March 2020
Primary completion	1 March 2021
Estimated completion	1 March 2021
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Prolotherapy — full drug profile →
Home based exercise program
Hotpack therapy

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Turkish League Against Rheumatism

Who can join

Adults 40 to 70, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study, the investigators aimed to compare the efficacy of %5, %10 and %20 concentration dextrose prolotherapy (DPT) treatments in patients with primary knee osteoarthritis (OA). In this prospective, randomized, controlled, single-blind study, 128 patients who met the inclusion criteria were recruited and divided into four groups. Thirty patients from each group completed the study. %5 DPT was applied to Group 1, %10 to Group 2, and %20 to Group 3 in combination with home exercise program and hotpack therapy. Group 4 was given home exercise program and hotpack therapy. Groups were evaluated with VAS (Visual Analog Scale), WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), knee ROM (Range of Motion), and Timed up and go test (TUG) parameters. DPT groups were evaluated in terms of side effects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A comparative analysis of prolotherapy efficacy in patients with knee osteoarthritis across varied dextrose concentrations.
Öztürk MU, Baygutalp F. · · 2023 · cited 2× · PMID 37540383 · DOI 10.1007/s10067-023-06723-4

Verify or expand the search:

Other trials of Prolotherapy

Trials testing the same drug.

NCT07399145 — Comparison of Prolotherapy and Rehabilitation Treatments in Low Back Pain (CPRTLBP) · NA · completed
NCT07355712 — Combined Effect of Prolotherapy and Personalized Physical Activity on Knee Osteoarthritis Progression · NA · completed
NCT06700746 — Efficacy of Dextrose Prolotherapy Compare With ESWT in the Treatment of Chronic Rotator Cuff Tendinopathy · NA · completed
NCT06161038 — Precision Medicine for Nociception, Sngception and Proprioception. · NA · recruiting
NCT06712329 — Chronic Plantar Fasciitis: Which is More Effective? Prolotherapy/Extracorporeal Shock Wave Therapy? · NA · completed

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Turkish League Against Rheumatism trials

Trials by the same sponsor.

NCT06256679 — RADIOFREQUENCY TREATMENT OF CHRONIC PELVIC PAIN MANAGEMENT IN INTERSTITIAL CYSTITIS · completed
NCT06451471 — "Galectin-3 as a Marker of Subclinical Inflammation in FMF" · completed
NCT04742296 — The Effects of Low-level Laser Therapy in Extensor Tendon Injuries Between Zones 5-8 · NA · completed
NCT04782401 — The Effects of Ultrasound Guided Genicular Nerve Block for Knee Osteoarthritis · NA · completed
NCT04153825 — Comparison of Effectiveness of Two Different Electrotherapy Agents on Central Sensitization · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05537077 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Turkish League Against Rheumatism
Last refreshed: 13 September 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05537077.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing