NCT04782401

The Effects of Ultrasound Guided Genicular Nerve Block for Knee Osteoarthritis

Completed NA Last updated 7 February 2022

What this trial tests

NA trial testing Ultrasound guided genicular nerve block + exercise treatment in Knee Osteoarthritis in 102 participants. Completed in 15 February 2021.

Timeline

1 March 2020

Primary endpoint
1 February 2021

15 February 2021

Quick facts

Lead sponsor	Turkish League Against Rheumatism
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	102
Start date	1 March 2020
Primary completion	1 February 2021
Estimated completion	15 February 2021
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Ultrasound guided genicular nerve block + exercise treatment
• Physical therapy + exercise treatment

Conditions studied

• Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Turkish League Against Rheumatism

Who can join

Adults 45 to 70, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Goal: Comparison of the effects of genicular nerve block with usg and physical therapy on pain, physical function for patients with knee osteoarthritis.

Material and Methods:102 patients with osteoarthritis of the knee with Kellgren-Lawrence (K-L) class 2 or 3 were included in the study.Patients were randomized to two groups, first being injected a total of 6 mL of lidocaine plus 40 mg of triamcinolone (TA) at 3 separate target sites: the superior lateral, superior medial, and inferior medial genicular nerves with exercise treatment and second being ten sessions of hotpack as a surface warmer, TENS as a analgezic current, ultrasound therapy as a deep warmer with exercise treatment.For the first group, the ultrasound we used: 12 MHz linear transducer. (Logic E9-GE, USA).The transducer was first placed parallel to the long bone shaft and moved up or down to identify the epicondyle of the long bone. The genicular arteries were identified near the periosteal areas, which are the junctions of the epicondyle and the shafts of the femur and tibia, and confirmed by color Doppler ultrasound.Accordingly, GNB target points should be next to each genicular artery because the superior lateral, superior medial, and inferior medial genicular artery traveled along each genicular nerve. , Visual Analogue Scale for pain(VAS) was primer outcome measurement, Western Ontorio and McMaster Universities Osteoarthritis Index (WOMAC) and six minute walk tests were seconder outcome measurements of the study applied before, after (two weeks) and 12th weeks of treatment. Primer endpoint of the study is decrease at least 40% in VAS values at 2nd week, second endpoint is the improvement in the womac and 6-minute walk test observed in the 2nd week continues until the 12th week.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Ultrasound-guided genicular nerve block versus physical therapy for chronic knee osteoarthritis: a prospective randomised study.
   Güler T, Yurdakul FG, Önder ME, Erdoğan F, et al · · 2022 · cited 13× · PMID 35165769 · DOI 10.1007/s00296-022-05101-8