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NCT05508503
A Study on a Blood-based Dual-target Test for CRC Detection
trial testing Test of methylated NTMT1 and MAP3K14-AS1 in Colorectal Cancer in 1,378 participants. Completed in 11 August 2023.
11 August 2023
Quick facts
| Lead sponsor | Changhai Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,378 |
| Start date | 21 October 2022 |
| Primary completion | 11 August 2023 |
| Estimated completion | 11 August 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Test of methylated NTMT1 and MAP3K14-AS1
- FIT
Conditions studied
- Colorectal Cancer — all drugs for Colorectal Cancer →
- Colorectal Adenoma — all drugs for Colorectal Adenoma →
Sponsor
Changhai Hospital
Who can join
Eligibility, any sex, with Colorectal Cancer or Colorectal Adenoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Circulating tumor DNA methylation detection as biomarker and its application in tumor liquid biopsy: advances and challenges.
Li L, Sun Y. · · 2024 · cited 52× · PMID 39525954 · DOI 10.1002/mco2.766 -
Liquid biopsies in cancer.
Yin H, Zhang M, Zhang Y, Zhang X, et al · · 2025 · cited 16× · PMID 40108089 · DOI 10.1186/s43556-025-00257-8 -
Evaluation of a plasma cell-free DNA methylation test for colorectal cancer diagnosis: a multicenter clinical study.
Wang Z, He Z, Lin R, Feng Z, et al · · 2024 · cited 3× · PMID 39379942 · DOI 10.1186/s12916-024-03662-y -
A panorama of colon cancer in the era of liquid biopsy.
Devalle S, Aran V, Bastos Júnior CS, Pannain VL, et al · · 2024 · PMID 40027146 · DOI 10.1016/j.jlb.2024.100148
Verify or expand the search:
- PubMed search for NCT05508503
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Changhai Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05508503 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Changhai Hospital
- Last refreshed: 16 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05508503.
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