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NCT05505682
Impact of Project Wolbachia - Singapore on Dengue Incidence
NA trial testing Biological (Male Wolbachia-infected Aedes aegypti) in Dengue in 724,428 participants. Completed in 13 September 2024.
13 September 2024
Quick facts
| Lead sponsor | National Environment Agency, Singapore |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 724,428 |
| Start date | 28 July 2022 |
| Primary completion | 13 September 2024 |
| Estimated completion | 13 September 2024 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- Biological (Male Wolbachia-infected Aedes aegypti) — full drug profile →
Conditions studied
- Dengue — all drugs for Dengue →
Sponsor
National Environment Agency, Singapore
Who can join
Eligibility, any sex, with Dengue. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study is a cluster-randomised controlled trial set in Singapore, to assess if the deployment of male Wolbachia-infected Aedes aegypti mosquitoes can reduce dengue incidence in intervention clusters.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Assessing the efficacy of male Wolbachia-infected mosquito deployments to reduce dengue incidence in Singapore: study protocol for a cluster-randomized controlled trial.
Ong J, Ho SH, Soh SXH, Wong Y, et al · · 2022 · cited 25× · PMID 36528590 · DOI 10.1186/s13063-022-06976-5 -
Update to: Assessing the efficacy of male Wolbachia-infected mosquito deployments to reduce dengue incidence in Singapore.
Lim JT, Mailepessov D, Chong CS, Chang CC, et al · · 2024 · cited 6× · PMID 38902790 · DOI 10.1186/s13063-024-08148-z -
Dengue Suppression by Male Wolbachia-Infected Mosquitoes.
Lim JT, Chong CS, Chang CC, Mailepessov D, et al · · 2026 · cited 1× · PMID 41671481 · DOI 10.1056/nejmoa2503304
Verify or expand the search:
- PubMed search for NCT05505682
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Biological (Male Wolbachia-infected Aedes aegypti)
Trials testing the same drug.
- NCT06894901 — Impact of IIT-SIT on Dengue Clusters · NA · recruiting
Other recruiting trials for Dengue
Currently open trials in the same condition.
- NCT07501793 — Demographic Characteristics of TAK-003 Dengue Vaccine Recipients in Vietnam · active not recruiting
- NCT07358910 — Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective · recruiting
- NCT07007585 — Risk Factors for Hospitalization and Transfusion Criteria in Patients With Dengue Virus Infection · recruiting
- NCT06894901 — Impact of IIT-SIT on Dengue Clusters · NA · recruiting
- NCT07158190 — Evaluation of T-cell Responses After Vaccination With the Attenuated Tetravalent Dengue Vaccine (Takeda). · active not recruiting
Other National Environment Agency, Singapore trials
Trials by the same sponsor.
- NCT06894901 — Impact of IIT-SIT on Dengue Clusters · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05505682 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Environment Agency, Singapore
- Last refreshed: 22 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05505682.
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