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NCT05505279
Ventilatory Effects of THRIVE During EBUS
Phase 3 trial testing THRIVE (High Flow Nasal Cannula) in Hypercapnia in 20 participants. Completed in 8 August 2024.
8 August 2024
Quick facts
| Lead sponsor | Rijnstate Hospital |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 20 |
| Start date | 5 October 2022 |
| Primary completion | 8 August 2024 |
| Estimated completion | 8 August 2024 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- THRIVE (High Flow Nasal Cannula)
Conditions studied
- Hypercapnia — all drugs for Hypercapnia →
- Sedation Complication — all drugs for Sedation Complication →
- High Flow Nasal Cannula — all drugs for High Flow Nasal Cannula →
Sponsor
Rijnstate Hospital
Who can join
18 and older, any sex, with Hypercapnia or Sedation Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
High flow nasal cannula (HFNC) is used in interventional procedures to prevent hypoxia during sedation. In patients with a patent airway, HFNC reduces dead space ventilation as well. It is unknown if dead space ventilation is also reduced by HFNC in an EndoBroncheal UltraSound procedure, in which the airway is partially blocked by the endoscope. Especially in patients with Chronic Obstructive Pulmonary Disease (COPD) the partial blocking of the airway may reduce ventilation. If HFNC is able to reduce dead space during an EBUS-procedure, it may facilitate CO2 clearance, which may lead to a reduction in work of breathing. This study aims to investigate if HFNC reduces dead space ventilation in patients undergoing an EBUS-procedure and if this is flow-dependent. A randomized, double-blinded, cross-over study is designed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05505279
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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- NCT05829083 — DUET Versus Standard Interface for Hypercapnic COPD Patients · NA · recruiting
- NCT05536076 — Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury · NA · recruiting
Other Rijnstate Hospital trials
Trials by the same sponsor.
- NCT07070583 — Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure · NA · recruiting
- NCT07304401 — Evaluation of Effectiveness of Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy for Treatment of Chemotherapy Induce · recruiting
- NCT06883591 — Triaxial Accelerometry Study · active not recruiting
- NCT06827509 — Blood Flow Evaluation After Carotid Surgical Treatment · not yet recruiting
- NCT05633550 — Flexion-Extension Radiograph Imaging Protocol Reliability Study · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05505279 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rijnstate Hospital
- Last refreshed: 15 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05505279.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing