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NCT06827509: BEAT
Blood Flow Evaluation After Carotid Surgical Treatment
trial testing Ultrasound-based flow imaging in Carotid Endarterectomy in 40 participants. Not yet recruiting.
31 December 2025
Quick facts
| Lead sponsor | Rijnstate Hospital |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 1 September 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 1 April 2026 |
Drugs / interventions tested
- Ultrasound-based flow imaging
Conditions studied
- Carotid Endarterectomy — all drugs for Carotid Endarterectomy →
Sponsor
Rijnstate Hospital
Who can join
18 and older, any sex, with Carotid Endarterectomy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Approximately 20% of strokes originate from the rupture of an atherosclerotic plaque in the carotid artery. Surgical revascularization, i.e. carotid endarterectomy (CEA), is the treatment of choice for patients with a symptomatic carotid stenosis each year about 3,000 procedures are performed in the Netherlands. Currently, two surgical procedures are performed in clinical practice. Most frequently an endarterectomy is performed using a length incision over the artery, followed by a patch plasty (CEAP), in order to reduce the risk of restenosis. As an alternative the eversion technique (ET) was introduced, in which transversal arteriotomy is performed and the plaque is removed from within. After reconstruction with a patch a \>50% restenosis has been described in 6-36% of patients during long-term follow-up. When using the eversion technique this is seen in 1.7-2.5%, while also the risk on adverse events seem to be lower. One of the drivers for atherosclerosis in general is a disturbance of local blood flow. This may lead to turbulence, recirculation and stasis of blood. The subsequent low Wall Shear Stress may lead to the ne formation of plaque that in turn may become instable and cause recurrent ischemic events. Recently, a breakthrough was achieved in the imaging options of flow in the carotid arteries, using Vector Flow Imaging. Using a fully programmable ultrasound machine, over 10,000 frames per second can be captured, in comparison to about 50 in regular ultrasound. This enables the tracking of particles that, after processing will provide the needed flow information. A recent study, comparing flow before and after CEAP has shown that there is significant recirculation after reconstruction. This raises the question whether this would be more optimal after ET, which would support the potential lower incidence of recurrent stenosis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06827509
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other trials of Ultrasound-based flow imaging
Trials testing the same drug.
- NCT05270005 — Progression Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound Flow Imaging · active not recruiting
Other recruiting trials for Carotid Endarterectomy
Currently open trials in the same condition.
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- NCT05198635 — Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy · recruiting
- NCT04347785 — Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia · recruiting
Other Rijnstate Hospital trials
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- NCT06184633 — DUTCH Weight Control in Atrial Fibrillation Study · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06827509 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rijnstate Hospital
- Last refreshed: 5 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06827509.
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