NCT05504044

To Study the Effects of Co-ingesting Different Forms of Almond, Almond Paste, Fibre, and Almond Phytochemicals With Bread on Postprandial Glucose and Insulin Profiles

Completed NA Last updated 31 August 2023

What this trial tests

NA trial testing Glucose control in Cardiovascular Diseases in 15 participants. Completed in 18 January 2023.

Timeline

25 October 2019

Primary endpoint
18 January 2023

18 January 2023

Quick facts

Lead sponsor	Singapore Institute of Food and Biotechnology Innovation
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	15
Start date	25 October 2019
Primary completion	18 January 2023
Estimated completion	18 January 2023
Sites	1 location across Singapore

Drugs / interventions tested

• Glucose control
• Bread control
• Almond paste
• Almond paste and inulin
• Low dose almond paste and inulin

Conditions studied

• Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
• Metabolic Disease — all drugs for Metabolic Disease →

Sponsor

Singapore Institute of Food and Biotechnology Innovation

Who can join

Adults 21 to 60, male only, with Cardiovascular Diseases or Metabolic Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Food is emerging as the new medicine. There has been growing evidence of the beneficial effects of foods, including nuts on human health. Modulation of both glucose and insulin are at the heart of reducing the risk of cardiovascular and other metabolic diseases. The contribution that nuts have on human health has been studied extensively and it is well established that the consumption of nuts revealed improvements in both blood glucose profile and reduced the risk of coronary heart diseases. Nuts, such as almonds, are nutrient-dense foods that are particularly rich in a-tocopherol. They are excellent sources of protein (\~25% of energy) and fibre, low in saturated fatty acid content (4-6%) and high in monounsaturated fatty acids. They also contain significant amounts of essential micronutrients such as folate (B vitamin) and polyphenols. Recently, strong interests on the health effects of nuts improving metabolic syndrome and controlling diabetes has been reported. Preliminary studies have indicated that the inclusion of nuts in the diets of individuals with diabetes and/or metabolic syndrome may improve postprandial glycaemic response, and lipid metabolism in the long run.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Harnessing Nature's Toolbox: Naturally Derived Bioactive Compounds in Nanotechnology Enhanced Formulations.
   Sanjai C, Gaonkar SL, Hakkimane SS. · · 2024 · cited 10× · PMID 39494011 · DOI 10.1021/acsomega.4c07756
2. Almond paste and dietary fibre: a novel way to improve postprandial glucose and lipid profiles?
   Bi X, Yeo MTY, Jeyakumar Henry C. · · 2022 · cited 1× · PMID 36329602 · DOI 10.1080/09637486.2022.2141207