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NCT05503212: BRAVO
Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions
trial testing Conservative treatment (CT) in Ischemic Stroke in 682 participants. Completed in 9 August 2023.
9 August 2023
Quick facts
| Lead sponsor | Centre Hospitalier Universitaire Vaudois |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 682 |
| Start date | 1 January 2003 |
| Primary completion | 9 August 2023 |
| Estimated completion | 9 August 2023 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Conservative treatment (CT)
- Intravenous thrombolysis (IVT)
- Endovascular thrombectomy (EVT) ± intravenous thrombolysis (IVT)
Conditions studied
- Ischemic Stroke — all drugs for Ischemic Stroke →
- Vertebral Artery Ischemia — all drugs for Vertebral Artery Ischemia →
- Arterial Occlusive Diseases — all drugs for Arterial Occlusive Diseases →
- Vertebrobasilar Insufficiency — all drugs for Vertebrobasilar Insufficiency →
Sponsor
Centre Hospitalier Universitaire Vaudois
Who can join
18 and older, any sex, with Ischemic Stroke or Vertebral Artery Ischemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes. If the two recent ATTENTION and BAOCHE randomized clinical trials have proven the superiority of endovascular thrombectomy (EVT) in basilar artery occlusions, data on the effectiveness and harm of acute revascularization treatment on isolated VAO is scarce. We aim to investigate the impact of acute recanalisation treatments in acute ischemic stroke patients with isolated VAO. In the absence of RCT, observational data with appropriate statistical methods may give indications on benefits and harms of treating neglected stroke situations like acute vertebral occlusion. Results may also lay the basis for prospective studies, such as randomized clinical trials.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Outcomes and Safety of Revascularization Approaches for Stroke Related to Isolated Vertebral Artery Occlusions (BRAVO).
Salerno A, Dunet V, Sykora M, Baumgartner P, et al · · 2026 · cited 1× · PMID 41804648 · DOI 10.1161/strokeaha.125.051675 -
ESOC 2023 Abstract Book
· 2023
Verify or expand the search:
- PubMed search for NCT05503212
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Related trials
Other recruiting trials for Ischemic Stroke
Currently open trials in the same condition.
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Other Centre Hospitalier Universitaire Vaudois trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05503212 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire Vaudois
- Last refreshed: 14 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05503212.
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