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NCT05496608
Treatment of Intrabony Defects With L-PRF Membrane With or Without Collagen Membranes
NA trial testing L-PRF in Periodontal Bone Loss in 63 participants. Completed in 1 February 2022.
30 November 2021
Quick facts
| Lead sponsor | Future University in Egypt |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 63 |
| Start date | 1 January 2021 |
| Primary completion | 30 November 2021 |
| Estimated completion | 1 February 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- L-PRF
- OFD
- CM
Conditions studied
- Periodontal Bone Loss — all drugs for Periodontal Bone Loss →
- Periodontal Diseases — all drugs for Periodontal Diseases →
Sponsor
Future University in Egypt
Who can join
Adults 30 to 50, any sex, with Periodontal Bone Loss or Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
For patients having periodontal intrabony lesions, three treatment modalities were executed to evaluate the effect of protecting Leukocyte rich -Platelet Rich Fibrin harvests (applied in the bony defects) with resorbable collagen membranes. Clinical Outcomes recorded were the Plaque index (PI), Gingival index (GI), probing depth reduction (PD), Clinical attachment level (CAL), and radiographic defect depth changes. For the biochemical evaluation: levels of PDGF-BB and VEGF obtained from crevicular fluid by Perio-Paper strips were assessed using ELIZA.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Adjunctive effect of collagen membrane coverage to L-PRF in the treatment of periodontal intrabony defects: a randomized controlled clinical trial with biochemical assessment.
Mubarak R, Adel-Khattab D, Abdel-Ghaffar KA, Gamal AY. · · 2023 · cited 9× · PMID 37667213 · DOI 10.1186/s12903-023-03332-0
Verify or expand the search:
- PubMed search for NCT05496608
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of L-PRF
Trials testing the same drug.
- NCT06663982 — Connective Tissue Graft and Leucocyte - Platelet Rich Fibrin in Alveolar Ridge Preservation · NA · not yet recruiting
- NCT07011303 — Investigation of the Effect of Horizontal Platelet Rich Fibrin Placed in Tooth Extraction Sockets on Bone Formation · NA · enrolling by invitation
- NCT06886438 — Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial · NA · completed
- NCT07387913 — Evaluation of the Effect of Leucocyte Platelet-Rich Fibrin (L-PRF) Technique Applied in Post-extraction Sockets Before P · NA · active not recruiting
- NCT05563519 — Comparison of the Efficacy of I-Prf Impregnated Collagen and L-Prf on Healing After Impacted Third Molar Surgery · NA · unknown
Other recruiting trials for Periodontal Bone Loss
Currently open trials in the same condition.
- NCT07146776 — Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts · NA · recruiting
- NCT06744348 — Entire Papilla Preservation Technique in the Treatment of Periodontal IntraBony Defects: a 1-year Follow-up Study · active not recruiting
- NCT05533528 — Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment · NA · recruiting
- NCT03997578 — Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects · NA · recruiting
Other Future University in Egypt trials
Trials by the same sponsor.
- NCT07347925 — Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF · recruiting
- NCT07129720 — Educational Program to Improve Dental Interns, Knowledge ,Attitude and Awareness Toward Molar Incisor Hypo-mineralizatio · NA · completed
- NCT07193342 — Effect of Computer-controlled vs. Conventional Injection on Pain and Anxiety in Children · NA · completed
- NCT06950762 — Aesthetic Performance of Two Injectable Resin Composites in Class V Cavities: A Randomized Clinical Trial · NA · not yet recruiting
- NCT06882343 — Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05496608 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Future University in Egypt
- Last refreshed: 25 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05496608.
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