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NCT05494294

Comparison of Different De-epithelialization Techniques of Soft Tissue Grafts.

Completed NA Last updated 11 August 2022
What this trial tests

NA trial testing Intraorally de-epithelialization in Connective Tissue Graft Harvesting in 50 participants. Completed in 5 August 2022.

Timeline
4 July 2021
Primary endpoint
30 July 2022
5 August 2022

Quick facts

Lead sponsorHacettepe University
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingtriple
Primary purposetreatment
Enrollment50
Start date4 July 2021
Primary completion30 July 2022
Estimated completion5 August 2022
Sites1 location across Turkey (Türkiye)

Drugs / interventions tested

Conditions studied

Sponsor

Hacettepe University

Who can join

Adults 18 to 60, any sex, with Connective Tissue Graft Harvesting. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this randomized comparative controlled clinical trial, 50 patients with single recession defects with thin phenotype were treated with coronally advanced flap. The connective tissue graft was obtained by removing the keratinized layer of the tissue. Removal of the epithelium was achieved by to different approach. At first group epithelium and remnants were removed extraorally whereas others were intraorally. After the removal, obtained graft laid on a lamella, and residual keratinocytes were observed under the microscope. Amount of recession reduction recorded at the 6th week, 6th month, 12th month, and keratinized tissue height, gingival thickness, recession depth, recession width, probing depth, and clinical attachment level, were also evaluated. Keratinized tissue change, Gingival thickness change, root coverage, clinical attachment gain, and complete root coverage were calculated. Wound healing index, tissue appearance, patient expectations, aesthetics, and dentine hypersensitivity were assessed at baseline and 6th week.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Efficacy of different gingival graft de-epithelialization methods: A parallel-group randomized clinical trial.
    Din F, Kabalak MÖ, Yılmaz BT, Barış E, et al · · 2025 · cited 1× · PMID 40332625 · DOI 10.1007/s00784-025-06365-7

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