NCT05471765

Effects of Continuous Positive Airway Pressure Therapy Withdrawal in Patients With Obstructive Sleep Apnea: A Randomized Trial

Status unknown NA Last updated 25 July 2022

What this trial tests

NA trial testing Withdrawal of Continuous Positive Airway Pressure device in Obstructive Sleep Apnea in 60 participants. Status unknown.

Timeline

23 March 2020

Primary endpoint
30 November 2022

30 December 2022

Quick facts

Lead sponsor	King Abdulaziz University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	60
Start date	23 March 2020
Primary completion	30 November 2022
Estimated completion	30 December 2022
Sites	1 location across Saudi Arabia

Drugs / interventions tested

• Withdrawal of Continuous Positive Airway Pressure device
• Alternation usage of Continuous Positive Airway Pressure Device

Conditions studied

• Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →

Sponsor

King Abdulaziz University

Who can join

Adults 18 to 75, any sex, with Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study design (e.g., double-blind:

A randomized, open-labeled, controlled, parallel-group study.

Sixty patients will be recruited with moderate to severe Obstructive Sleep Apnea (OSA), previously adherent to CPAP therapy and have controlled OSA defined as Apnea Hypopnea Index (AHI) of \< 5 while on treatment. Patients will be divided into two groups after completion of Therapeutic CPAP, Who will continue on same CPAP therapy for 4 weeks they will be randomized into two groups:

1. NO CPAP (NOCPAP Group): Who will stop using the CPAP device.
2. Intermittent CPAP (Int-CPAP Group): Who will use the CPAP device every other night.

This trial will also evaluate the effects of CPAP withdrawal (complete or partial) on excessive day time sleepiness (EDS), apnea hypopnea index (AHI), Heart Rate and Blood Pressure.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Impact of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial.
   Wali SO, Batawi G, Kanbr O, Butt NS, et al · · 2025 · cited 2× · PMID 40167853 · DOI 10.1007/s11325-025-03309-z