NCT05442073

Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

Completed Last updated 1 July 2022

What this trial tests

trial testing PEEP adjustment in ARDS, Human in 18 participants. Completed in 29 June 2022.

Timeline

1 March 2022

Primary endpoint
31 May 2022

29 June 2022

Quick facts

Lead sponsor	Peking Union Medical College Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	18
Start date	1 March 2022
Primary completion	31 May 2022
Estimated completion	29 June 2022
Sites	1 location across China

Drugs / interventions tested

• PEEP adjustment

Conditions studied

• ARDS, Human — all drugs for ARDS, Human →
• PEEP, Occult — all drugs for PEEP, Occult →
• Esophageal and Pleural Pressure — all drugs for Esophageal and Pleural Pressure →

Sponsor

Peking Union Medical College Hospital

Who can join

Adults 18 to 90, any sex, with ARDS, Human or PEEP, Occult. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Phenotypes of esophageal pressure response to the change of positive end-expiratory pressure in patients with moderate acute respiratory distress syndrome.
   Cheng W, Jiang J, Long Y, Yuan S, et al · · 2024 · cited 1× · PMID 38505046 · DOI 10.21037/jtd-23-771