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NCT06321497
Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury
trial testing Extracorporeal carbon dioxide removal in ARDS, Human in 15 participants. Currently enrolling.
28 February 2027
Quick facts
| Lead sponsor | Peninsula Health |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 15 |
| Start date | 5 February 2024 |
| Primary completion | 28 February 2027 |
| Estimated completion | 28 February 2028 |
| Sites | 1 location across Australia |
Drugs / interventions tested
- Extracorporeal carbon dioxide removal
Conditions studied
- ARDS, Human — all drugs for ARDS, Human →
Sponsor
Peninsula Health
Who can join
18 and older, any sex, with ARDS, Human. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lung protective ventilation with low tidal volumes and low driving pressure are known to reduce mortality in mechanically ventilated patients with acute respiratory failure. This reduction in mortality is known be due to reduction of ventilator induced lung injury that occurs due to high tidal volumes and high driving pressure. When receiving such mechanical ventilation, some patients develop hypercapnia and associated hypercapnic acidosis. Such patients have an increased risk of mortality. While the exact reasons for such increase in mortality is not known, it is recommended to minimise hypercapnia and hypercapnic acidosis during lung protective ventilation. Minimally invasive extracorporeal carbon dioxide removal (ECCO2R) devices are shown to reduce hypercapnia and hypercapnic acidosis. There are several devices that are currently available in the current clinical practice. However, the effect of these devices on reduction in ventilator induced lung injury is not clearly demonstrated. This study aims to assess the use of an ECCO2R device called Prismalung in reducing ventilator induced lung injury. PrismaLung is currently used in our intensive care unit. This assessment is done by measuring interleukins in bronchoalveolar lavage fluid and blood interleukin levels as well as clinical assessment including the reduction of driving pressure.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06321497
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Related trials
Other trials of Extracorporeal carbon dioxide removal
Trials testing the same drug.
- NCT03584295 — Early Extubation by ECCO2R Compared to IMV in Patients with Severe Acute Exacerbation of COPD · NA · terminated
Other recruiting trials for ARDS, Human
Currently open trials in the same condition.
- NCT07070362 — Digital Early Warning System for Acute Lung Injury in Liver Surgery · recruiting
- NCT06572280 — Non-invasive Phrenic Nerve Stimulation in ARDS Patient · NA · recruiting
- NCT06119516 — Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study. · NA · recruiting
- NCT06486259 — Regional Assessment of the Risk of Lung Injury in Ventilated Patients · recruiting
- NCT05795257 — Pulmonary Immune Cell-microbiome Interactions in ARDS · recruiting
Other Peninsula Health trials
Trials by the same sponsor.
- NCT06398951 — HFNC vs Two Nare HFNC in Extubated Patients · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06321497 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Peninsula Health
- Last refreshed: 20 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06321497.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing