NCT05422274 is a NA clinical trial of Transcranial Pulse Stimulation in ADHD, sponsored by The Hong Kong Polytechnic University.

Who is sponsoring NCT05422274?

NCT05422274 is sponsored by The Hong Kong Polytechnic University.

What drugs are being tested in NCT05422274?

Interventions in NCT05422274: Transcranial Pulse Stimulation.

Is NCT05422274 still recruiting?

NCT05422274 is currently completed. Last updated 13 March 2025.

Last reviewed 2025-03-13 · How we verify

NCT05422274

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Transcranial Pulse Stimulation on ADHD

Completed NA Last updated 13 March 2025

What this trial tests

NA trial testing Transcranial Pulse Stimulation in ADHD in 32 participants. Completed in 13 January 2023.

Timeline

1 June 2022

Primary endpoint
13 January 2023

13 January 2023

Quick facts

Lead sponsor	The Hong Kong Polytechnic University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	32
Start date	1 June 2022
Primary completion	13 January 2023
Estimated completion	13 January 2023
Sites	1 location across Hong Kong

Drugs / interventions tested

Transcranial Pulse Stimulation

Conditions studied

ADHD — all drugs for ADHD →

Sponsor

The Hong Kong Polytechnic University

Who can join

Adults 12 to 17, any sex, with ADHD. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is the first nationwide study using Transcranial Pulse Stimulation to evaluate its efficacy and safety on 30 young adolescents with ADHD. Six verum/ shamTPS sessions will be delivered to all subjects on a 1: 1 ratio, balanced by gender and age. Attention deficit, hyperactivity, impulsivity, and oppositional defiance will be the primary outcome. Secondary outcomes include ADHD severity, frequency of inattention, hyperactivity, impulsivity, executive function and neural connectivity changes via neuroimaging. Results emerging from this study will generate new knowledge to ascertain whether TPS can be used as a top-on treatment in ADHD.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Current state of clinical ultrasound neuromodulation.
Matt E, Radjenovic S, Mitterwallner M, Beisteiner R. · · 2024 · cited 27× · PMID 38962179 · DOI 10.3389/fnins.2024.1420255
Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial.
Cheung T, Yee BK, Chau B, Lam JYT, et al · · 2024 · cited 12× · PMID 38784916 · DOI 10.3389/fneur.2024.1364270
Evaluating the efficacy and safety of transcranial pulse stimulation on adolescents with attention deficit hyperactivity disorder: Study protocol of a pilot randomized, double-blind, sham-controlled trial.
Cheung T, Chau B, Fong KH, Lam JYT, et al · · 2023 · cited 4× · PMID 37056363 · DOI 10.3389/fneur.2023.1076086

Verify or expand the search:

Other trials of Transcranial Pulse Stimulation

Trials testing the same drug.

NCT05408793 — Effects of Transcranial Pulse Stimulation on ASD · NA · completed
NCT05006365 — EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT · NA · completed

Other recruiting trials for ADHD

Currently open trials in the same condition.

NCT07314333 — A Trial to Assess How Centanafadine Interacts With Stimulants in the Body · Phase 1 · recruiting
NCT07262853 — Dual Executive Function Training Package · NA · recruiting
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NCT07281092 — Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) · NA · recruiting
NCT07219810 — Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD · NA · recruiting

Other The Hong Kong Polytechnic University trials

Trials by the same sponsor.

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NCT07450248 — The Use of Telephone-based ACT for Quitting Alcohol in the Young Population With Hazardous or Harmful Alcohol Use. · NA · not yet recruiting
NCT07273682 — Nurse-led Transitional Care to Improve Symptom Management in Childhood Cancer Survivors · NA · not yet recruiting
NCT07531082 — Effects of a Salutogenic Strength-based Social Robot-assisted Intervention on the Depressive Symptoms and Sense of Coher · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05422274 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Hong Kong Polytechnic University
Last refreshed: 13 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05422274.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing