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NCT05421169: ICE-HEAT
Diastolic Hyperemia-Free Ratio in Patients With CAD
trial testing diastolic hyperemia-free ratio (DFR) in Coronary Stenosis in 300 participants. Completed in 7 March 2024.
21 February 2024
Quick facts
| Lead sponsor | Yonsei University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 300 |
| Start date | 23 August 2022 |
| Primary completion | 21 February 2024 |
| Estimated completion | 7 March 2024 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- diastolic hyperemia-free ratio (DFR)
Conditions studied
- Coronary Stenosis — all drugs for Coronary Stenosis →
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Yonsei University
Who can join
19 and older, any sex, with Coronary Stenosis or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators aimed to identify the value of concordance between the diastolic hyperemia-free ratio (DFR) and fractional flow reserve (FFR) during pre-interventional and post-interventional period using a 0.014" COMET II Pressure Guidewire
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Diastolic Hyperemia-Free Ratio in Patients With Coronary Artery Disease: A Prospective Observational Study.
Roh JW, Lee OH, Kim Y, Heo SJ, et al · · 2025 · cited 1× · PMID 40206008 · DOI 10.4070/kcj.2024.0351
Verify or expand the search:
- PubMed search for NCT05421169
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Yonsei University trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05421169 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yonsei University
- Last refreshed: 15 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05421169.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing