NCT05417061 is a NA clinical trial of Saliva and serum sampling in Periodontitis, sponsored by Istanbul Medipol University Hospital.

Who is sponsoring NCT05417061?

NCT05417061 is sponsored by Istanbul Medipol University Hospital.

What drugs are being tested in NCT05417061?

Interventions in NCT05417061: Saliva and serum sampling.

What condition does NCT05417061 study?

NCT05417061 studies Periodontitis, Diagnose Disease.

Is NCT05417061 still recruiting?

NCT05417061 is currently completed. Last updated 23 October 2023.

Last reviewed 2023-10-23 · How we verify

NCT05417061

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Serum and Saliva Sirtuin 6, Lipoxin A4, Caspase8 Levels in Correlation With Periodontal Status in Severe Periodontitis

Completed NA Last updated 23 October 2023

What this trial tests

NA trial testing Saliva and serum sampling in Periodontitis in 40 participants. Completed in 30 May 2022.

Timeline

14 October 2021

Primary endpoint
21 April 2022

30 May 2022

Quick facts

Lead sponsor	Istanbul Medipol University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	40
Start date	14 October 2021
Primary completion	21 April 2022
Estimated completion	30 May 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Saliva and serum sampling

Conditions studied

Periodontitis — all drugs for Periodontitis →
Diagnose Disease — all drugs for Diagnose Disease →

Sponsor

Istanbul Medipol University Hospital

Who can join

Adults 18 to 65, any sex, with Periodontitis or Diagnose Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It has been stated that Sirtuin-6 (SIRT6) play a important role in regulation of inflammation, energy metabolism, homeostasis and apoptosis, and SIRT6 may be assosiciated with many diseases. The aim of this study was to evaluate saliva and serum SIRT6, Lipoxin A4 (LXA4) and Caspase-8 (CASP8) levels in correlation with periodontal clinical status in patients with periodontitis and healthy subjects

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Lipoxins as Modulators of Diseases.
Saqib U, Pandey M, Vyas A, Patidar P, et al · · 2025 · cited 4× · PMID 40862723 · DOI 10.3390/cells14161244
Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis.
Cekici A, Sahinkaya S, Donmez MF, Turkmen E, et al · · 2023 · cited 3× · PMID 37851128 · DOI 10.1007/s00784-023-05330-6
SIRT3/6/7: promising therapeutic targets for pulmonary fibrosis.
Huang P, Qin D, Qin Y, Tao S, et al · · 2025 · cited 2× · PMID 40241794 · DOI 10.3389/fcell.2025.1557384
Editorial: Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis, volume II.
Qiu Y, Tang XX, Shichino S, Kushwaha PP, et al · · 2025 · PMID 40874025 · DOI 10.3389/fcell.2025.1653034

Verify or expand the search:

Other trials of Saliva and serum sampling

Trials testing the same drug.

NCT06580431 — Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease · NA · completed
NCT07182448 — Hypoxia and Kynurenine Pathway in Periodontal Inflammation · completed
NCT07272564 — Kynurenine Pathway in Parkinson's Disease · NA · completed
NCT05448976 — Potential Effect for the Smoking on Periodontitis From the Perspective of Arginine Metabolites · NA · completed

Other recruiting trials for Periodontitis

Currently open trials in the same condition.

NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting

Other Istanbul Medipol University Hospital trials

Trials by the same sponsor.

NCT07508371 — Menthol Massage for Post-Bypass Pain & Anxiety · NA · not yet recruiting
NCT07575477 — Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery · NA · not yet recruiting
NCT07525115 — Effects of Proprioceptive Neuromuscular Facilitation-Based Lower Extremity Training on Balance, Gait, and Functional Ind · NA · not yet recruiting
NCT07467278 — Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome · NA · not yet recruiting
NCT07468864 — Validity of the Turkish Situational Vertigo Questionnaire · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05417061 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istanbul Medipol University Hospital
Last refreshed: 23 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05417061.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing