Last reviewed · How we verify
NCT05415020: RLB
Determining the Utility of a Behavioral Intervention in Chronic Migraine
NA trial testing Lifestyle Behavior Protocol in Migraine in 60 participants. Currently enrolling.
1 July 2026
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 29 June 2022 |
| Primary completion | 1 July 2026 |
| Estimated completion | 14 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Lifestyle Behavior Protocol
- Sham Behavior Protocol
Conditions studied
- Migraine — all drugs for Migraine →
- Headache — all drugs for Headache →
- Migraine Disorders — all drugs for Migraine Disorders →
- Chronic Migraine — all drugs for Chronic Migraine →
Sponsor
Mayo Clinic
Who can join
18 and older, any sex, with Migraine or Headache. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protocol. Successful completion of this proposal will inform the design of a future full-scale behavioral clinical trial to control chronic migraine.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Has the COVID-19 pandemic changed characteristics, administration modalities, and implementation of psychological interventions for chronic headache? An updated systematic review.
De Lucia A, Donisi V, Rimondini M, Del Piccolo L, et al · · 2026 · PMID 41923926 · DOI 10.1080/21642850.2026.2650006
Verify or expand the search:
- PubMed search for NCT05415020
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Migraine
Currently open trials in the same condition.
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- NCT07343427 — Impact of GON PRF on Central Sensitization in Migraine Patients · NA · active not recruiting
- NCT07336056 — Nerivio Efficacy Under High-Frequency Use · Phase 4 · active not recruiting
- NCT07385755 — Desvenlafaxine for Preventive Treatment of Frequent Migraines · NA · active not recruiting
Other Mayo Clinic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05415020 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 3 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05415020.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing