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NCT05413382
Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)
NA trial testing Biofresh® 4plus in Halitosis in 53 participants. Completed in 22 December 2021.
4 November 2021
Quick facts
| Lead sponsor | Novozymes A/S |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 53 |
| Start date | 28 September 2021 |
| Primary completion | 4 November 2021 |
| Estimated completion | 22 December 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Biofresh® 4plus
- Placebo
Conditions studied
- Halitosis — all drugs for Halitosis →
Sponsor
Novozymes A/S
Who can join
18 and older, any sex, with Halitosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is designed to evaluate the effect of an investigational lozenge with the enzyme polyphenol oxidase and green coffee extract in reducing and controlling intra-oral halitosis following immediate use and daily use of the lozenge over a one-week period.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05413382
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Halitosis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT06900881 — Role of Kefir Mouth Wash in Oral Health Status Amelioration · Phase 2, PHASE3 · recruiting
- NCT06882564 — Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis. · Phase 3 · recruiting
- NCT06583720 — Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis · Phase 1 · recruiting
- NCT06483646 — Evaluation of the Stability of Sulfur Volatile Compounds From Exhaled Air for Halitosis Diagnosis · NA · recruiting
Other Novozymes A/S trials
Trials by the same sponsor.
- NCT07163637 — Effect of Limosilactobacillus Reuteri DSM 17648 in Healthy Adults Reporting Upper Gastrointestinal Discomfort · NA · recruiting
- NCT06107088 — Effect of a Combination of Lactase and L. Salivarius DSM 34078 in Individuals With Lactose Intolerance · NA · completed
- NCT07079683 — RCT: Enzyme Blend Toothpaste on Dental Biofilm Plaque Accumulation · NA · completed
- NCT06142409 — Effect of Enzyme-containing Lozenge on Dental Biofilm Formation, Composition and Functionality · NA · completed
- NCT05507021 — Effect of Lactobacillus Plantarum DSM 33464 on Blood Lead Levels in Young Women of Child-bearing Age · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05413382 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Novozymes A/S
- Last refreshed: 10 June 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05413382.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing