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NCT05400863
Effect of NNS on Metformin/GDF15, Pilot
NA trial testing avoid sugary and NNS drinks plus start Metformin in Obesity, Adolescent in 46 participants. Completed in 2 August 2024.
2 August 2024
Quick facts
| Lead sponsor | University of Florida |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 46 |
| Start date | 21 April 2022 |
| Primary completion | 2 August 2024 |
| Estimated completion | 2 August 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- avoid sugary and NNS drinks plus start Metformin
- avoid sugary drinks (allowed water and drinks sweetened with NNS) plus start Metformin
Conditions studied
- Obesity, Adolescent — all drugs for Obesity, Adolescent →
- Pre Diabetes — all drugs for Pre Diabetes →
Sponsor
University of Florida
Who can join
Adults 10 to 21, any sex, with Obesity, Adolescent or Pre Diabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Metformin use for diabetes has the benefit of causing weight loss in some. The investigators in a preclinical trial, demonstrated that mice consuming non-nutritive sweetened (NNS) drinks had worse glucose improvements and weight loss than mice consuming sugar drinks or water. This study will conduct a pilot to determine if this translates into pediatric clinical practice. The hypothesis is that NNS drinks impair metformin-induced satiation, weight loss, and glucose tolerance.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05400863
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05400863 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Florida
- Last refreshed: 5 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05400863.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing