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NCT05394090
The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke
NA trial testing saliva stimulation in Periodontal Diseases in 50 participants. Completed in 26 April 2021.
26 April 2021
Quick facts
| Lead sponsor | Pomeranian Medical University Szczecin |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 50 |
| Start date | 24 January 2020 |
| Primary completion | 26 April 2021 |
| Estimated completion | 26 April 2021 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- saliva stimulation
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
- Saliva Altered — all drugs for Saliva Altered →
- Stroke — all drugs for Stroke →
Sponsor
Pomeranian Medical University Szczecin
Who can join
Adults 48 to 80, any sex, with Periodontal Diseases or Saliva Altered. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated. The severity of the neurological condition was assessed using the NIHSS scale on days 1, 3 and 7 of stroke. The incidence of periodontal diseases was classified using the Hall's scale in the 1st day of stroke. On days 1 and 7 of stroke, the concentration of IL-1beta, MMP8, OPG and RANKL in the patients' saliva was assessed using the Elisa technique. At the same time, the level of CRP and the number of leukocytes in the peripheral blood were tested on days 1, 3 and 7 of the stroke, and the incidence of upper respiratory and urinary tract infections was assessed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05394090
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Pomeranian Medical University Szczecin trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05394090 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pomeranian Medical University Szczecin
- Last refreshed: 27 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05394090.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing