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NCT05384405
aiTBS for Relieving NSSI in Depressive Patients
NA trial testing Active iTBS in Major Depressive Disorder in 60 participants. Currently enrolling.
28 February 2025
Quick facts
| Lead sponsor | Central South University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 July 2022 |
| Primary completion | 28 February 2025 |
| Estimated completion | 28 February 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Active iTBS
- Sham iTBS
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Bipolar Depression — all drugs for Bipolar Depression →
Sponsor
Central South University
Who can join
Adults 12 to 18, any sex, with Major Depressive Disorder or Bipolar Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Repetitive transcranial magnetic stimulation (rTMS) has been successfully used to help patients with treatment resistant depression. However, its role in alleviating self injuries without suicidal ideation remained uncertain. This trial will compare the effectiveness of active accelerated intermittent theta burst stimulation (aiTBS) rTMS to a placebo control on non-suicidal self injury (NSSI) in patients with unipolar disorder and bipolar disorder.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Intermittent theta burst stimulation for non-suicidal self-injury in adolescents with major depressive disorder: a randomized, sham-controlled trial.
Qin Y, Chen H, Liu F, Zou T, et al · · 2026 · cited 2× · PMID 40883451 · DOI 10.1038/s41380-025-03183-x
Verify or expand the search:
- PubMed search for NCT05384405
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Active iTBS
Trials testing the same drug.
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- NCT07106645 — Intermittent Theta Burst Transcranial Magnetic Stimulation of the Right Parietal Lobe in Anorexia Nervosa · NA · not yet recruiting
- NCT06770556 — Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study · NA · recruiting
- NCT06210100 — aiTBS for NSSI and Suicide in Adolescent Depression · NA · recruiting
- NCT05783063 — iTBS for Increased Appetite Induced by Antipsychotics · NA · recruiting
Other recruiting trials for Major Depressive Disorder
Currently open trials in the same condition.
- NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
- NCT06705478 — Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disor · Phase 2 · recruiting
- NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
- NCT07316803 — Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness · NA · recruiting
- NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting
Other Central South University trials
Trials by the same sponsor.
- NCT07444463 — Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications · NA · not yet recruiting
- NCT07446478 — TIS for Improving Cognitive Impairment Associated With Schizophrenia · NA · not yet recruiting
- NCT07045142 — Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia Patients · Phase 3 · recruiting
- NCT07066813 — Staging Strategies and Their Association With Prognosis and Therapy in Lung Cancer With Cystic Airspaces · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05384405 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Central South University
- Last refreshed: 1 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05384405.
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