Who is sponsoring NCT05383300?

NCT05383300 is sponsored by King's College London.

What drugs are being tested in NCT05383300?

Interventions in NCT05383300: Oxytocin nasal spray, Placebo spray.

What condition does NCT05383300 study?

NCT05383300 studies Antisocial Personality Disorder.

Is NCT05383300 still recruiting?

NCT05383300 is currently completed. Last updated 20 May 2022.

Last reviewed 2022-05-20 · How we verify

NCT05383300: OXYASP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy

Completed NA Last updated 20 May 2022

What this trial tests

NA trial testing Oxytocin nasal spray in Antisocial Personality Disorder in 72 participants. Completed in 1 December 2021.

Timeline

1 May 2017

Primary endpoint
1 March 2020

1 December 2021

Quick facts

Lead sponsor	King's College London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	other
Enrollment	72
Start date	1 May 2017
Primary completion	1 March 2020
Estimated completion	1 December 2021
Sites	1 location across United Kingdom

Drugs / interventions tested

Oxytocin nasal spray — full drug profile →
Placebo spray

Conditions studied

Antisocial Personality Disorder — all drugs for Antisocial Personality Disorder →

Sponsor

King's College London

Who can join

Adults 18 to 60, male only, with Antisocial Personality Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A pharmacoimaging study of oxytcoin in antisocial personality disorder and psychopathy

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Oxytocin normalizes the implicit processing of fearful faces in psychopathy: a randomized crossover study using fMRI.
Tully J, Sethi A, Griem J, Paloyelis Y, et al · · 2023 · cited 15× · PMID 38665476 · DOI 10.1038/s44220-023-00067-3
Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy.
Griem J, Martins D, Tully J, Murphy D, et al · · 2026 · PMID 41582219 · DOI 10.1038/s41598-026-36661-5
Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy
Griem J, Martins D, Tully J, Murphy D, et al · · 2025 · DOI 10.1101/2025.04.08.25325470

Verify or expand the search:

Other trials of Oxytocin nasal spray

Trials testing the same drug.

NCT07162584 — Oxytocin and Human Defensive Responses in a Dynamic Situation · NA · recruiting
NCT06194851 — Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD · Phase 2 · recruiting
NCT05934812 — Intranasal Oxytocin in Youth With Autism · Phase 2 · not yet recruiting
NCT06881810 — Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to Psychosocial Treatment · Phase 2 · recruiting
NCT06332066 — Oxytocin Administration to Therapists and Its Effects on Patient-perceived Attunement and Responsiveness · Phase 1 · unknown

Other recruiting trials for Antisocial Personality Disorder

Currently open trials in the same condition.

NCT06176638 — Resettled Refugee Families for Healing · NA · active not recruiting

Other King's College London trials

Trials by the same sponsor.

NCT07357064 — Professional Decision Making in Childbirth. · not yet recruiting
NCT07341087 — Skin Inflammation in Perimenopause: A Probiotic Intervention Proof of Concept Trial · NA · recruiting
NCT07228962 — Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies · not yet recruiting
NCT07365722 — Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants. · NA · not yet recruiting
NCT07378488 — Dance/Movement Therapy for Functional Neurological Disorder · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05383300 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by King's College London
Last refreshed: 20 May 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05383300.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing