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NCT05382260

Personal Music for Disorders of Consciousness

Status unknown NA Last updated 23 January 2023
What this trial tests

NA trial testing Listening to music in Disorder of Consciousness in 45 participants. Status unknown.

Timeline
26 May 2022
Primary endpoint
31 December 2023
31 December 2023

Quick facts

Lead sponsorQiuyou Xie
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationnon randomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment45
Start date26 May 2022
Primary completion31 December 2023
Estimated completion31 December 2023
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

Qiuyou Xie

Who can join

Adults 18 to 70, any sex, with Disorder of Consciousness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: The evaluation and treatment of disorders of consciousness(DOC) is a challenging undertaking. Now many neuroimaging techniques were used to detect the level of consciousness and electroencephagram(EEG) was widely used because of its high temporal resolution. Music would be an effective for DOC, due to its highly arousal value. Preferred music was near to persons, so that it would excite more range of cortical and increase the functional connectivity between cortices. Methods: The exploratory study included 15 health controls and 30 DOC, with 15 minimally conscious state(MCS) and 15 vegetative state(VS). After 5 minutes baseline silence, they listened to relaxing music(RM), preferred music(PM) and amplitude modulated sound(AMS), with 5 minutes baseline silence in the end, meanwhile EEG recorded their cortical activity. Each music was appropriately 5 minutes and separated by 3 minutes washout. Discussion: The study would verify the effect of preferred music to the functional connectivity of DOC. Music would excite the networks related to consciousness by cross-modal.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Individualized music induces theta-gamma phase-amplitude coupling in patients with disorders of consciousness.
    Xiao Q, Zheng X, Wen Y, Yuan Z, et al · · 2024 · cited 3× · PMID 39010944 · DOI 10.3389/fnins.2024.1395627

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Other trials of Listening to music

Trials testing the same drug.

Other recruiting trials for Disorder of Consciousness

Currently open trials in the same condition.

Other Qiuyou Xie trials

Trials by the same sponsor.

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