NCT05380687 (TONES) is a NA clinical trial of Inspiratory hold in Ventilator Weaning, sponsored by University Hospital, Antwerp.

Who is sponsoring NCT05380687?

NCT05380687 is sponsored by University Hospital, Antwerp.

What drugs are being tested in NCT05380687?

Interventions in NCT05380687: Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles, PEEP 10, PEEP 5, PEEP 0.

What condition does NCT05380687 study?

NCT05380687 studies Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure, Critical Care.

Is NCT05380687 still recruiting?

NCT05380687 is currently completed. Last updated 4 April 2025.

Last reviewed 2025-04-04 · How we verify

NCT05380687: TONES

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training

Completed NA Last updated 4 April 2025

What this trial tests

NA trial testing Inspiratory hold in Ventilator Weaning in 1 participant. Completed in 31 December 2023.

Timeline

15 June 2022

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	University Hospital, Antwerp
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	diagnostic
Enrollment	1
Start date	15 June 2022
Primary completion	31 December 2023
Estimated completion	31 December 2023
Sites	1 location across Belgium

Drugs / interventions tested

Inspiratory hold
Expiratory hold
Ultrasound of respiratory muscles
PEEP 10
PEEP 5
PEEP 0

Conditions studied

Ventilator Weaning — all drugs for Ventilator Weaning →
Respiration, Artificial — all drugs for Respiration, Artificial →
Respiratory Muscles — all drugs for Respiratory Muscles →
Respiratory Failure — all drugs for Respiratory Failure →

Sponsor

University Hospital, Antwerp

Who can join

Adults 18 to 80, any sex, with Ventilator Weaning or Respiration, Artificial. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The TONES trial aims to evaluate the neuroventilatory efficiency (NVE = tidal volume / peak voltage of diaphragm contraction) measured during a zero-assist manoeuvre (ZAM, i.e. with PEEP but without pressure support). This novel parameter, NVE-ZAM, will be studied in a blocked, crossover, repeated measures design. Possible confounders, such as activity of respiratory muscles other than the diaphragm, are included. The investigators hypothesized that * the NVE during a zero-assist maneuver has a low variability and high repeatability at the same level of PEEP (within subjects, within blocks) * NVE-ZAM trends differ between participants (between subjects, within blocks) and between PEEP levels (within subjects, between blocks) The primary aim is to study the variability and repeatability of the NVE-ZAM within subjects and within blocks. Additionally, the effect of PEEP, muscle fatigue and recruitment of the accessory and expiratory muscles of respiration on the NVE-ZAM will be studied in an exploratory analysis (in multiple combinations of within and between subjects and/or blocks).

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Ventilator Weaning

Currently open trials in the same condition.

NCT07098611 — A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score · recruiting
NCT06499389 — Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients · NA · recruiting
NCT06662201 — Association Between P0.1 and Extubation Failure in Adult Patients With Acute Hypoxemic Respiratory Failure. A Multicente · active not recruiting
NCT04222205 — Spontaneous Breathing Trial With T-piece or Inspiratory Pressure Augmentation · NA · active not recruiting

Other University Hospital, Antwerp trials

Trials by the same sponsor.

NCT07455422 — A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurr · NA · not yet recruiting
NCT07020715 — A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis · Phase 2 · not yet recruiting
NCT07443761 — Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital. · active not recruiting
NCT06372847 — DISE-HNS Effect Study · NA · recruiting
NCT07189091 — CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05380687 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Antwerp
Last refreshed: 4 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05380687.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing